John G. Doench
John G. Doench
Broad Institute
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Zitiert von
Zitiert von
Genome-scale CRISPR-Cas9 knockout screening in human cells
O Shalem, NE Sanjana, E Hartenian, X Shi, DA Scott, TS Mikkelsen, ...
Science 343 (6166), 84-87, 2014
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ...
Nature biotechnology 34 (2), 184-191, 2016
A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
A Subramanian, R Narayan, SM Corsello, DD Peck, TE Natoli, X Lu, ...
Cell 171 (6), 1437-1452. e17, 2017
Specificity of microRNA target selection in translational repression
JG Doench, PA Sharp
Genes & development 18 (5), 504-511, 2004
siRNAs can function as miRNAs
JG Doench, CP Petersen, PA Sharp
Genes & development 17 (4), 438-442, 2003
Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
JG Doench, E Hartenian, DB Graham, Z Tothova, M Hegde, I Smith, ...
Nature biotechnology 32 (12), 1262-1267, 2014
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
VS Viswanathan, MJ Ryan, HD Dhruv, S Gill, OM Eichhoff, ...
Nature 547 (7664), 453-457, 2017
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
RT Manguso, HW Pope, MD Zimmer, FD Brown, KB Yates, BC Miller, ...
Nature 547 (7664), 413-418, 2017
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma
B Chapuy, MR McKeown, CY Lin, S Monti, MGM Roemer, J Qi, PB Rahl, ...
Cancer cell 24 (6), 777-790, 2013
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
D Pan, A Kobayashi, P Jiang, L Ferrari de Andrade, RE Tay, AM Luoma, ...
Science 359 (6377), 770-775, 2018
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities
KR Sanson, RE Hanna, M Hegde, KF Donovan, C Strand, ME Sullender, ...
Nature communications 9 (1), 5416, 2018
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Y Zou, MJ Palte, AA Deik, H Li, JK Eaton, W Wang, YY Tseng, R Deasy, ...
Nature communications 10 (1), 1617, 2019
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ...
Nature cancer 1 (2), 235-248, 2020
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
JJ Ishizuka, RT Manguso, CK Cheruiyot, K Bi, A Panda, A Iracheta-Vellve, ...
Nature 565 (7737), 43-48, 2019
Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis
Y Zou, H Li, ET Graham, AA Deik, JK Eaton, W Wang, G Sandoval-Gomez, ...
Nature chemical biology 16 (3), 302-309, 2020
Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
J Wei, MM Alfajaro, PC DeWeirdt, RE Hanna, WJ Lu-Culligan, WL Cai, ...
Cell 184 (1), 76-91. e13, 2021
Mutational processes shape the landscape of TP53 mutations in human cancer
AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ...
Nature genetics 50 (10), 1381-1387, 2018
Am I ready for CRISPR? A user's guide to genetic screens
JG Doench
Nature Reviews Genetics 19 (2), 67-80, 2018
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
J Wei, L Long, W Zheng, Y Dhungana, SA Lim, C Guy, Y Wang, YD Wang, ...
Nature 576 (7787), 471-476, 2019
A genome-wide CRISPR death screen identifies genes essential for oxidative phosphorylation
JD Arroyo, AA Jourdain, SE Calvo, CA Ballarano, JG Doench, DE Root, ...
Cell metabolism 24 (6), 875-885, 2016
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