Hubert Kettenberger
Hubert Kettenberger
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Zitiert von
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
W Schaefer, JT Regula, M Bähner, J Schanzer, R Croasdale, H Dürr, ...
Proceedings of the National academy of Sciences 108 (27), 11187-11192, 2011
Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS
H Kettenberger, KJ Armache, P Cramer
Molecular cell 16 (6), 955-965, 2004
Structure of eukaryotic RNA polymerases
P Cramer, KJ Armache, S Baumli, S Benkert, F Brueckner, C Buchen, ...
Annu. Rev. Biophys. 37, 337-352, 2008
Architecture of the RNA polymerase II-TFIIS complex and implications for mRNA cleavage
H Kettenberger, KJ Armache, P Cramer
Cell 114 (3), 347-357, 2003
Architecture of initiation-competent 12-subunit RNA polymerase II
KJ Armache, H Kettenberger, P Cramer
Proceedings of the National Academy of Sciences 100 (12), 6964-6968, 2003
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
C Klein, C Sustmann, M Thomas, K Stubenrauch, R Croasdale, ...
MAbs 4 (6), 653-663, 2012
Developability assessment during the selection of novel therapeutic antibodies
A Jarasch, H Koll, JT Regula, M Bader, A Papadimitriou, H Kettenberger
Journal of pharmaceutical sciences 104 (6), 1885-1898, 2015
Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics
A Schoch, H Kettenberger, O Mundigl, G Winter, J Engert, J Heinrich, ...
Proceedings of the National Academy of Sciences 112 (19), 5997-6002, 2015
Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions
JF Sydow, F Lipsmeier, V Larraillet, M Hilger, B Mautz, M Mølhøj, ...
PloS one 9 (6), e100736, 2014
Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry
PF Jensen, V Larraillet, T Schlothauer, H Kettenberger, M Hilger, ...
Molecular & Cellular Proteomics 14 (1), 148-161, 2015
Structure of an RNA polymerase II–RNA inhibitor complex elucidates transcription regulation by noncoding RNAs
H Kettenberger, A Eisenführ, F Brueckner, M Theis, M Famulok, P Cramer
Nature structural & molecular biology 13 (1), 44-48, 2006
Bispecific anti-VEGF/anti-ANG-2 antibodies
M Baehner, U Brinkmann, G Georges, RA Griep, S Imhof-Jung, A Kavlie, ...
US Patent 8,268,314, 2012
Impact of molecular processing in the hinge region of therapeutic IgG4 antibodies on disposition profiles in cynomolgus monkeys
K Stubenrauch, U Wessels, JT Regula, H Kettenberger, J Schleypen, ...
Drug Metabolism and Disposition 38 (1), 84-91, 2010
Structure–function studies of the RNA polymerase II elongation complex
F Brueckner, KJ Armache, A Cheung, GE Damsma, H Kettenberger, ...
Acta Crystallographica Section D: Biological Crystallography 65 (2), 112-120, 2009
Bispecific, bivalent anti-vegf/anti-ang-2 antibodies
M Baehner, S Imhof-Jung, A Kavlie, H Kettenberger, C Klein, J Thomas, ...
US Patent 8,945,552, 2015
Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis
TE Kraft, WF Richter, T Emrich, A Knaupp, M Schuster, A Wolfert, ...
MAbs 12 (1), 1683432, 2020
Ocular half-life of intravitreal biologics in humans and other species: meta-analysis and model-based prediction
A Caruso, M Füth, R Alvarez-Sánchez, S Belli, C Diack, KF Maass, ...
Molecular Pharmaceutics 17 (2), 695-709, 2019
A simple strategy for preparation of sensor arrays: Molecularly structured monolayers as recognition elements
T Hirsch, H Kettenberger, OS Wolfbeis, VM Mirsky
Chemical communications, 432-433, 2003
Crystal structure of an anti-Ang2 CrossFab demonstrates complete structural and functional integrity of the variable domain
S Fenn, CB Schiller, JJ Griese, H Duerr, S Imhof-Jung, C Gassner, ...
PLoS One 8 (4), e61953, 2013
XGFR*, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic …
JM Schanzer, K Wartha, E Moessner, RJ Hosse, S Moser, R Croasdale, ...
MAbs 8 (4), 811-827, 2016
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