| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13594* | 2021 |
| Protein phase separation: a new phase in cell biology S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ... Trends in cell biology 28 (6), 420-435, 2018 | 1820 | 2018 |
| Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration B Oosthuyse, L Moons, E Storkebaum, H Beck, D Nuyens, K Brusselmans, ... Nature genetics 28 (2), 131-138, 2001 | 1373 | 2001 |
| Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy OV Evgrafov, I Mersiyanova, J Irobi, L Van Den Bosch, I Dierick, CL Leung, ... Nature genetics 36 (6), 602-606, 2004 | 752 | 2004 |
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ... Nature neuroscience 18 (9), 1226-1229, 2015 | 669 | 2015 |
| Genome-wide analyses identify KIF5A as a novel ALS gene A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ... Neuron 97 (6), 1267-1288, 2018 | 648 | 2018 |
| Hallmarks of neurodegenerative diseases DM Wilson, MR Cookson, L Van Den Bosch, H Zetterberg, DM Holtzman, ... Cell 186 (4), 693-714, 2023 | 640 | 2023 |
| Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS E Storkebaum, D Lambrechts, M Dewerchin, MP Moreno-Murciano, ... Nature neuroscience 8 (1), 85-92, 2005 | 627 | 2005 |
| The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis L Van Den Bosch, P Van Damme, E Bogaert, W Robberecht Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1762 (11-12 …, 2006 | 618 | 2006 |
| HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1–induced Charcot-Marie-Tooth disease C d'Ydewalle, J Krishnan, DM Chiheb, P Van Damme, J Irobi, ... Nature medicine 17 (8), 968-974, 2011 | 575 | 2011 |
| Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics S Boeynaems, E Bogaert, D Kovacs, A Konijnenberg, E Timmerman, ... Molecular cell 65 (6), 1044-1055. e5, 2017 | 533 | 2017 |
| Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy J Irobi, KV Impe, P Seeman, A Jordanova, I Dierick, N Verpoorten, ... Nature genetics 36 (6), 597-601, 2004 | 511 | 2004 |
| Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival P Van Damme, A Van Hoecke, D Lambrechts, P Vanacker, E Bogaert, ... The Journal of cell biology 181 (1), 37-41, 2008 | 474 | 2008 |
| Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy A Jordanova, J Irobi, FP Thomas, P Van Dijck, K Meerschaert, M Dewil, ... Nature genetics 38 (2), 197-202, 2006 | 449 | 2006 |
| Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties S Boeynaems, AS Holehouse, V Weinhardt, D Kovacs, J Van Lindt, ... Proceedings of the National Academy of Sciences 116 (16), 7889-7898, 2019 | 414 | 2019 |
| HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients W Guo, M Naujock, L Fumagalli, T Vandoorne, P Baatsen, R Boon, ... Nature communications 8 (1), 861, 2017 | 373 | 2017 |
| Minocycline delays disease onset and mortality in a transgenic model of ALS L Van Den Bosch, P Tilkin, G Lemmens, W Robberecht Neuroreport 13 (8), 1067-1070, 2002 | 370 | 2002 |
| EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans A Van Hoecke, L Schoonaert, R Lemmens, M Timmers, KA Staats, ... Nature medicine 18 (9), 1418-1422, 2012 | 365 | 2012 |
| Calcium dysregulation in amyotrophic lateral sclerosis J Grosskreutz, L Van Den Bosch, BU Keller Cell calcium 47 (2), 165-174, 2010 | 358 | 2010 |
| Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration CL Simpson, R Lemmens, K Miskiewicz, WJ Broom, VK Hansen, ... Human molecular genetics 18 (3), 472-481, 2009 | 358 | 2009 |
