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Neil T. Umbreit
Neil T. Umbreit
Dana-Farber Cancer Institute
Verified email at dfci.harvard.edu
Title
Cited by
Cited by
Year
Mechanisms generating cancer genome complexity from a single cell division error
NT Umbreit, CZ Zhang, LD Lynch, LJ Blaine, AM Cheng, R Tourdot, L Sun, ...
Science 368 (6488), eaba0712, 2020
3362020
Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B
JF Tien, NT Umbreit, DR Gestaut, AD Franck, J Cooper, L Wordeman, ...
Journal of Cell Biology 189 (4), 713-723, 2010
2442010
The Ndc80 kinetochore complex directly modulates microtubule dynamics
NT Umbreit, DR Gestaut, JF Tien, BS Vollmar, T Gonen, CL Asbury, ...
Proceedings of the National Academy of Sciences 109 (40), 16113-16118, 2012
1412012
Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation
NT Umbreit, MP Miller, JF Tien, J Cattin Ortolá, L Gui, KK Lee, S Biggins, ...
Nature communications 5 (1), 4951, 2014
632014
The Ndc80 complex bridges two Dam1 complex rings
J Kim, A Zelter, NT Umbreit, A Bollozos, M Riffle, R Johnson, MJ MacCoss, ...
Elife 6, e21069, 2017
602017
The molecular architecture of the Dam1 kinetochore complex is defined by cross-linking based structural modelling
A Zelter, M Bonomi, JO Kim, NT Umbreit, MR Hoopmann, R Johnson, ...
Nature communications 6 (1), 8673, 2015
602015
Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex
EM Kudalkar, EA Scarborough, NT Umbreit, A Zelter, DR Gestaut, M Riffle, ...
Proceedings of the National Academy of Sciences 112 (41), E5583-E5589, 2015
562015
The molecular architecture of the yeast spindle pole body core determined by Bayesian integrative modeling
S Viswanath, M Bonomi, SJ Kim, VA Klenchin, KC Taylor, KC Yabut, ...
Molecular biology of the cell 28 (23), 3298-3314, 2017
472017
Coupling Unbiased Mutagenesis to High-throughput DNA Sequencing Uncovers Functional Domains in the Ndc80 Kinetochore Protein of Saccharomyces cerevisiae
JF Tien, KK Fong, NT Umbreit, C Payen, A Zelter, CL Asbury, MJ Dunham, ...
Genetics 195 (1), 159-170, 2013
292013
Kinetochore Biorientation in Saccharomyces cerevisiae Requires a Tightly Folded Conformation of the Ndc80 Complex
JF Tien, NT Umbreit, A Zelter, M Riffle, MR Hoopmann, RS Johnson, ...
Genetics 198 (4), 1483-1493, 2014
272014
Cdk1 phosphorylation of the Dam1 complex strengthens kinetochore-microtubule attachments
A Gutierrez, J ook Kim, NT Umbreit, CL Asbury, TN Davis, MP Miller, ...
Current Biology 30 (22), 4491-4499. e5, 2020
152020
Cell biology: when your own chromosomes act like foreign DNA
A Spektor, NT Umbreit, D Pellman
Current Biology 27 (22), R1228-R1231, 2017
152017
Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor
AL Jiao, R Perales, NT Umbreit, JR Haswell, ME Piper, BD Adams, ...
Rna 25 (3), 352-363, 2019
142019
Mechanisms generating cancer genome complexity from a single cell division error. Science 368, eaba0712
NT Umbreit, CZ Zhang, LD Lynch, LJ Blaine, AM Cheng, R Tourdot, L Sun, ...
132020
Mitosis puts sisters in a strained relationship: force generation at the kinetochore
NT Umbreit, TN Davis
Experimental cell research 318 (12), 1361-1366, 2012
132012
Genome jail-break triggers lockdown
NT Umbreit, D Pellman
Nature 550 (7676), 340-341, 2017
122017
VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro
LJ Laine, JHE Mäki-Jouppila, E Kutvonen, P Tiikkainen, TKM Nyholm, ...
Oncoscience 8, 134, 2021
12021
A Bayesian Integrative Structure Model of the Yeast Centrosome
S Viswanath, M Bonomi, SJ Kim, VA Klenchin, K Taylor, KC Yabut, ...
Biophysical Journal 114 (3), 35a, 2018
2018
ORC is not essential for DNA replication in human cell lines, but important for repressing Rb-E2F and Polycomb group regulated genes.
A Spektor, C Zhang, N Umbreit, M Feldman, A Ahsan, Y Zhang, ...
MOLECULAR BIOLOGY OF THE CELL 27, 2016
2016
DNA damage and chromothripsis from chromosome segregation errors.
A Spektor, Z Cheng-Zhong, NT Umbreit, H Cornils, JM Francis, ...
MOLECULAR BIOLOGY OF THE CELL 26, 2015
2015
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