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Reem K. Arafa
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In vitro anticancer screening and radiosensitizing evaluation of some new quinolines and pyrimido [4, 5-b] quinolines bearing a sulfonamide moiety
MM Ghorab, FA Ragab, HI Heiba, RK Arafa, EM El-Hossary
European journal of medicinal chemistry 45 (9), 3677-3684, 2010
1272010
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo [1, 2-a] pyridines and 5, 6, 7, 8-tetrahydro-imidazo [1, 2-a] pyridines
MA Ismail, RK Arafa, T Wenzler, R Brun, FA Tanious, WD Wilson, ...
Bioorganic & medicinal chemistry 16 (2), 683-691, 2008
1122008
Synthesis and in vitro antiproliferative effect of novel quinoline-based potential anticancer agents
RK Arafa, GH Hegazy, GA Piazza, AH Abadi
European journal of medicinal chemistry 63, 826-832, 2013
922013
Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs
RK Arafa, R Brun, T Wenzler, FA Tanious, WD Wilson, CE Stephens, ...
Journal of medicinal chemistry 48 (17), 5480-5488, 2005
892005
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: terphenyl diamidines and analogues
MA Ismail, RK Arafa, R Brun, T Wenzler, Y Miao, WD Wilson, C Generaux, ...
Journal of medicinal chemistry 49 (17), 5324-5332, 2006
862006
Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif
M Munde, MA Ismail, R Arafa, P Peixoto, CJ Collar, Y Liu, L Hu, ...
Journal of the American Chemical Society 129 (44), 13732-13743, 2007
812007
Comprehensive virtual screening of the antiviral potentialities of marine polycyclic guanidine alkaloids against SARS-CoV-2 (COVID-19)
A El-Demerdash, AM Metwaly, A Hassan, TM Abd El-Aziz, EB Elkaeed, ...
Biomolecules 11 (3), 460, 2021
802021
Triaryl dicationic DNA minor-groove binders with antioxidant activity display cytotoxicity and induce apoptosis in breast cancer
MS Nafie, K Arafa, NK Sedky, AA Alakhdar, RK Arafa
Chemico-biological interactions 324, 109087, 2020
712020
Novel anti-HIV-1 NNRTIs based on a pyrazolo [4, 3-d] isoxazole backbone scaffold: design, synthesis and insights into the molecular basis of action
SM Gomha, MG Badrey, MM Abdalla, RK Arafa
MedChemComm 5 (11), 1685-1692, 2014
632014
Design, synthesis and structure–activity relationship of novel semi-synthetic flavonoids as antiproliferative agents
FA Ragab, TAA Yahya, MM El-Naa, RK Arafa
European journal of medicinal chemistry 82, 506-520, 2014
612014
Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: synthesis, cytotoxic activity and molecular modeling
MM Ghorab, M Ceruso, MS Alsaid, YM Nissan, RK Arafa, CT Supuran
European Journal of Medicinal Chemistry 87, 186-196, 2014
602014
Molecular determinants for DNA minor groove recognition: design of a bis-guanidinium derivative of ethidium that is highly selective for AT-rich DNA sequences
C Bailly, RK Arafa, FA Tanious, W Laine, C Tardy, A Lansiaux, P Colson, ...
Biochemistry 44 (6), 1941-1952, 2005
582005
Induced fit conformational changes of a “reversed amidine” heterocycle: optimized interactions in a DNA minor groove complex
M Munde, M Lee, S Neidle, R Arafa, DW Boykin, Y Liu, C Bailly, ...
Journal of the American Chemical Society 129 (17), 5688-5698, 2007
572007
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies
NA El-Sayed, MS Nour, MA Salem, RK Arafa
European Journal of Medicinal Chemistry 183, 111693, 2019
522019
Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues
MA Ismail, RK Arafa, MM Youssef, WM El-Sayed
Drug Design, Development and Therapy, 1659-1672, 2014
512014
Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents
RK Arafa, MA Ismail, M Munde, WD Wilson, T Wenzler, R Brun, ...
European journal of medicinal chemistry 43 (12), 2901-2908, 2008
412008
Synthesis and Antiprotozoal Activity of Dicationic m-Terphenyl and 1,3-Dipyridylbenzene Derivatives
DA Patrick, MA Ismail, RK Arafa, T Wenzler, X Zhu, T Pandharkar, ...
Journal of medicinal chemistry 56 (13), 5473-5494, 2013
402013
Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity
HSA ElZahabi, MS Nafie, D Osman, NH Elghazawy, DH Soliman, ...
European Journal of Medicinal Chemistry 222, 113609, 2021
392021
Synthesis and antiproliferative activity of monocationic arylthiophene derivatives
MA Ismail, MM Youssef, RK Arafa, SS Al-Shihry, WM El-Sayed
European journal of medicinal chemistry 126, 789-798, 2017
392017
Docking study, in vitro anticancer screening and radiosensitizing evaluation of some new fluorine-containing quinoline and pyrimidoquinoline derivatives bearing a sulfonamide …
MM Ghorab, FA Ragab, HI Heiba, RK Arafa, EM El-Hossary
Medicinal chemistry research 20, 388-400, 2011
362011
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