| Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening IJ Enyedy, Y Ling, K Nacro, Y Tomita, X Wu, Y Cao, R Guo, B Li, X Zhu, ... Journal of medicinal chemistry 44 (25), 4313-4324, 2001 | 465 | 2001 |
| Differential localization of protein kinase C δ by phorbol esters and related compounds using a fusion protein with green fluorescent protein QJ Wang, D Bhattacharyya, S Garfield, K Nacro, VE Marquez, ... Journal of Biological Chemistry 274 (52), 37233-37239, 1999 | 251 | 1999 |
| Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function S Lim, TY Saw, M Zhang, MR Janes, K Nacro, J Hill, AQ Lim, CT Chang, ... Proceedings of the National Academy of Sciences 110 (25), E2298-E2307, 2013 | 156 | 2013 |
| β2-Chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain MJ Caloca, ML Garcia-Bermejo, PM Blumberg, NE Lewin, E Kremmer, ... Proceedings of the National Academy of Sciences 96 (21), 11854-11859, 1999 | 132 | 1999 |
| Rescue of oxytocin response and social behaviour in a mouse model of autism H Hörnberg, E Pérez-Garci, D Schreiner, L Hatstatt-Burklé, F Magara, ... Nature 584 (7820), 252-256, 2020 | 120 | 2020 |
| Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C? K Nacro, B Bienfait, J Lee, KC Han, JH Kang, S Benzaria, NE Lewin, ... Journal of medicinal chemistry 43 (5), 921-944, 2000 | 94 | 2000 |
| Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor Y Li, Z Zhang, WW Phoo, YR Loh, R Li, HY Yang, AE Jansson, J Hill, ... Structure 26 (4), 555-564. e3, 2018 | 83 | 2018 |
| Structure-guided fragment-based in silico drug design of dengue protease inhibitors T Knehans, A Schüller, DN Doan, K Nacro, J Hill, P Güntert, ... Journal of computer-aided molecular design 25, 263-274, 2011 | 70 | 2011 |
| Role of hydrophobic residues in the C1b domain of protein kinase C δ on ligand and phospholipid interactions QJ Wang, TW Fang, K Nacro, VE Marquez, S Wang, PM Blumberg Journal of Biological Chemistry 276 (22), 19580-19587, 2001 | 68 | 2001 |
| Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives K Nacro, CC Zha, PR Guzzo, RJ Herr, D Peace, TD Friedrich Bioorganic & medicinal chemistry 15 (12), 4237-4246, 2007 | 55 | 2007 |
| The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands VE Marquez, K Nacro, S Benzaria, J Lee, R Sharma, K Teng, GWA Milne, ... Pharmacology & therapeutics 82 (2-3), 251-261, 1999 | 53 | 1999 |
| Attempt to rationalize the diastereoselectivity in the addition of ester enolate to optically active α, β-epoxyaldehydes K Nacro, M Baltas, L Gorrichon Tetrahedron 55 (49), 14013-14030, 1999 | 50 | 1999 |
| Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 C Hanau, S Mershon, M Graneto, M Meyers, S Hegde, I Buchler, K Wu, ... US Patent App. 10/742,494, 2004 | 44 | 2004 |
| Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin BF Molino, S Liu, A Sambandam, PR Guzzo, M Hu, C Zha, K Nacro, ... US Patent 7,956,050, 2011 | 43 | 2011 |
| Optimization of selective mitogen-activated protein kinase interacting kinases 1 and 2 inhibitors for the treatment of blast crisis leukemia H Yang, LR Chennamaneni, MWT Ho, SH Ang, ESW Tan, DA Jeyaraj, ... Journal of Medicinal Chemistry 61 (10), 4348-4369, 2018 | 40 | 2018 |
| Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C) DM Sigano, ML Peach, K Nacro, Y Choi, NE Lewin, MC Nicklaus, ... Journal of medicinal chemistry 46 (9), 1571-1579, 2003 | 36 | 2003 |
| Identification of covalent active site inhibitors of dengue virus protease X Koh-Stenta, J Joy, SF Wang, PZ Kwek, JLK Wee, KF Wan, S Gayen, ... Drug design, development and therapy, 6389-6399, 2015 | 34 | 2015 |
| Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations S Kannan, A Poulsen, HY Yang, M Ho, SH Ang, TSW Eldwin, DA Jeyaraj, ... Biochemistry 54 (1), 32-46, 2015 | 32 | 2015 |
| Exploring aigialomycin D and its analogues as protein kinase inhibitors for cancer targets J Xu, A Chen, ML Go, K Nacro, B Liu, CLL Chai ACS Medicinal Chemistry Letters 2 (9), 662-666, 2011 | 32 | 2011 |
| Conformationally Constrained Analogues of Diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG Lactones in Binding to Protein Kinase C H Tamamura, B Bienfait, K Nacro, NE Lewin, PM Blumberg, VE Marquez Journal of medicinal chemistry 43 (17), 3210-3217, 2000 | 31 | 2000 |
