Albena T. Dinkova-Kostova
Albena T. Dinkova-Kostova
Professor of Chemical Biology, University of Dundee
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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova, WD Holtzclaw, RN Cole, K Itoh, N Wakabayashi, ...
Proceedings of the National Academy of Sciences 99 (18), 11908-11913, 2002
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
JD Hayes, AT Dinkova-Kostova
Trends in biochemical sciences 39 (4), 199-218, 2014
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ...
Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004
The cytoprotective role of the Keap1–Nrf2 pathway
L Baird, AT Dinkova-Kostova
Archives of toxicology 85 (4), 241-272, 2011
Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
AT Dinkova-Kostova, MA Massiah, RE Bozak, RJ Hicks, P Talalay
Proceedings of the National Academy of Sciences 98 (6), 3404-3409, 2001
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
AT Dinkova-Kostova, KT Liby, KK Stephenson, WD Holtzclaw, X Gao, ...
Proceedings of the National Academy of Sciences 102 (12), 4584-4589, 2005
NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
AT Dinkova-Kostova, P Talalay
Archives of biochemistry and biophysics 501 (1), 116-123, 2010
Direct and indirect antioxidant properties of inducers of cytoprotective proteins
AT Dinkova‐Kostova, P Talalay
Molecular nutrition & food research 52 (S1), S128-S138, 2008
Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway
JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova
Antioxidants & redox signaling 13 (11), 1713-1748, 2010
Glucosinolates and isothiocyanates in health and disease
AT Dinkova-Kostova, RV Kostov
Trends in molecular medicine 18 (6), 337-347, 2012
The emerging role of Nrf2 in mitochondrial function
AT Dinkova-Kostova, AY Abramov
Free Radical Biology and Medicine 88, 179-188, 2015
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
LE Tebay, H Robertson, ST Durant, SR Vitale, TM Penning, ...
Free Radical Biology and Medicine 88, 108-146, 2015
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders
V Calabrese, C Cornelius, AT Dinkova-Kostova, EJ Calabrese, ...
Antioxidants & redox signaling 13 (11), 1763-1811, 2010
The role of Keap1 in cellular protective responses
AT Dinkova-Kostova, WD Holtzclaw, TW Kensler
Chemical research in toxicology 18 (12), 1779-1791, 2005
Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
L Ye, AT Dinkova-Kostova, KL Wade, Y Zhang, TA Shapiro, P Talalay
Clinica chimica acta 316 (1-2), 43-53, 2002
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
V Calabrese, C Cornelius, AT Dinkova-Kostova, I Iavicoli, R Di Paola, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (5), 753-783, 2012
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
BS Cornblatt, L Ye, AT Dinkova-Kostova, M Erb, JW Fahey, NK Singh, ...
Carcinogenesis 28 (7), 1485-1490, 2007
Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
TA Shapiro, JW Fahey, AT Dinkova-Kostova, WD Holtzclaw, ...
Nutrition and cancer 55 (1), 53-62, 2006
Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
P Talalay, AT Dinkova-Kostova, WD Holtzclaw
Advances in enzyme regulation 43, 121-134, 2003
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