Elizaveta (Lisa) Freinkman
Elizaveta (Lisa) Freinkman
Senior R&D Project Manager, Locus Biosciences
Verified email at
Cited by
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An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
K Birsoy, T Wang, WW Chen, E Freinkman, M Abu-Remaileh, DM Sabatini
Cell 162 (3), 540-551, 2015
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites
S Schwartz, MR Mumbach, M Jovanovic, T Wang, K Maciag, GG Bushkin, ...
Cell reports 8 (1), 284-296, 2014
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
LB Sullivan, DY Gui, AM Hosios, LN Bush, E Freinkman, ...
Cell 162 (3), 552-563, 2015
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
JR Mayers, ME Torrence, LV Danai, T Papagiannakopoulos, ...
Science 353 (6304), 1161-1165, 2016
Lysosomal metabolomics reveals V-ATPase-and mTOR-dependent regulation of amino acid efflux from lysosomes
M Abu-Remaileh, GA Wyant, C Kim, NN Laqtom, M Abbasi, SH Chan, ...
Science 358 (6364), 807-813, 2017
Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase
JR Cantor, M Abu-Remaileh, N Kanarek, E Freinkman, X Gao, ...
Cell 169 (2), 258-272. e17, 2017
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ...
Nature chemical biology 12 (6), 452-458, 2016
mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient
GA Wyant, M Abu-Remaileh, RL Wolfson, WW Chen, E Freinkman, ...
Cell 171 (3), 642-654. e12, 2017
Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism
WW Chen, E Freinkman, T Wang, K Birsoy, DM Sabatini
Cell 166 (5), 1324-1337. e11, 2016
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
D Kim, BP Fiske, K Birsoy, E Freinkman, K Kami, RL Possemato, ...
Nature 520 (7547), 363-367, 2015
Fasting activates fatty acid oxidation to enhance intestinal stem cell function during homeostasis and aging
MM Mihaylova, CW Cheng, AQ Cao, S Tripathi, MD Mana, ...
Cell stem cell 22 (5), 769-778. e4, 2018
Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin
DY Gui, LB Sullivan, A Luengo, AM Hosios, LN Bush, N Gitego, ...
Cell metabolism 24 (5), 716-727, 2016
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
J Garcia-Bermudez, L Baudrier, EC Bayraktar, Y Shen, K La, ...
Nature 567 (7746), 118-122, 2019
Histidine catabolism is a major determinant of methotrexate sensitivity
N Kanarek, HR Keys, JR Cantor, CA Lewis, SH Chan, T Kunchok, ...
Nature 559 (7715), 632-636, 2018
Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli
S Okuda, E Freinkman, D Kahne
Science 338 (6111), 1214-1217, 2012
Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming
M Vaeth, M Maus, S Klein-Hessling, E Freinkman, J Yang, M Eckstein, ...
Immunity 47 (4), 664-679. e6, 2017
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
YD Shaul, E Freinkman, WC Comb, JR Cantor, WL Tam, P Thiru, D Kim, ...
Cell 158 (5), 1094-1109, 2014
The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel
E Freinkman, SS Chng, D Kahne
Proceedings of the National Academy of Sciences 108 (6), 2486-2491, 2011
Metabolic reprogramming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities
J Franco, U Balaji, E Freinkman, AK Witkiewicz, ES Knudsen
Cell reports 14 (5), 979-990, 2016
Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export
E Freinkman, S Okuda, N Ruiz, D Kahne
Biochemistry 51 (24), 4800-4806, 2012
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