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Symen Ligthart
Symen Ligthart
Antwerp University Hospital
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Year
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
A Mahajan, D Taliun, M Thurner, NR Robertson, JM Torres, NW Rayner, ...
Nature genetics 50 (11), 1505-1513, 2018
15262018
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
BR Joubert, JF Felix, P Yousefi, KM Bakulski, AC Just, C Breton, ...
The American Journal of Human Genetics 98 (4), 680-696, 2016
8462016
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
A Mahajan, J Wessel, SM Willems, W Zhao, NR Robertson, AY Chu, ...
Nature genetics 50 (4), 559-571, 2018
4052018
Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders
S Ligthart, A Vaez, U Võsa, MG Stathopoulou, PS De Vries, BP Prins, ...
The American Journal of Human Genetics 103 (5), 691-706, 2018
3442018
The trans-ancestral genomic architecture of glycemic traits
J Chen, CN Spracklen, G Marenne, A Varshney, LJ Corbin, J Luan, ...
Nature genetics 53 (6), 840-860, 2021
3372021
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
S Ligthart, C Marzi, S Aslibekyan, MM Mendelson, KN Conneely, ...
Genome biology 17, 1-15, 2016
2842016
Lifetime risk of developing impaired glucose metabolism and eventual progression from prediabetes to type 2 diabetes: a prospective cohort study
S Ligthart, TTW van Herpt, MJG Leening, M Kavousi, A Hofman, ...
The lancet Diabetes & endocrinology 4 (1), 44-51, 2016
2602016
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns
BR Joubert, HT Den Dekker, JF Felix, J Bohlin, S Ligthart, E Beckett, ...
Nature communications 7 (1), 10577, 2016
2582016
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A Mahajan, CN Spracklen, W Zhang, MCY Ng, LE Petty, H Kitajima, ...
Nature genetics 54 (5), 560-572, 2022
2352022
Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study
L Chaker, S Ligthart, TIM Korevaar, A Hofman, OH Franco, RP Peeters, ...
BMC medicine 14 (1), 1-8, 2016
1942016
DNA methylation analysis identifies loci for blood pressure regulation
MA Richard, T Huan, S Ligthart, R Gondalia, MA Jhun, JA Brody, MR Irvin, ...
The American Journal of Human Genetics 101 (6), 888-902, 2017
1702017
Dissecting the association between inflammation, metabolic dysregulation, and specific depressive symptoms: a genetic correlation and 2-sample mendelian randomization study
N Kappelmann, J Arloth, MK Georgakis, D Czamara, N Rost, S Ligthart, ...
JAMA psychiatry 78 (2), 161-170, 2021
1652021
Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: a longitudinal study of 11 461 participants from population-based cohorts
G Agha, MM Mendelson, CK Ward-Caviness, R Joehanes, TX Huan, ...
Circulation 140 (8), 645-657, 2019
1622019
Pleiotropic genes for metabolic syndrome and inflammation
AT Kraja, DI Chasman, KE North, AP Reiner, LR Yanek, TO Kilpeläinen, ...
Molecular genetics and metabolism 112 (4), 317-338, 2014
1392014
Age at natural menopause and risk of type 2 diabetes: a prospective cohort study
T Muka, E Asllanaj, N Avazverdi, L Jaspers, N Stringa, J Milic, S Ligthart, ...
Diabetologia 60, 1951-1960, 2017
1212017
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
Interleukin 1 Genetics Consortium
The Lancet Diabetes & Endocrinology 3 (4), 243-253, 2015
1162015
Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits
AT Kraja, C Liu, JL Fetterman, M Graff, CT Have, C Gu, LR Yanek, ...
The American Journal of Human Genetics 104 (1), 112-138, 2019
1042019
Vitamin D and C-reactive protein: a Mendelian randomization study
MC Liefaard, S Ligthart, A Vitezova, A Hofman, AG Uitterlinden, ...
PloS one 10 (7), e0131740, 2015
962015
Serum magnesium and the risk of prediabetes: a population-based cohort study
BCT Kieboom, S Ligthart, A Dehghan, S Kurstjens, JHF de Baaij, ...
Diabetologia 60 (5), 843-853, 2017
952017
Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease: meta-analysis of six population-based cohorts
C Herder, T De Las Heras Gala, M Carstensen-Kirberg, C Huth, A Zierer, ...
Arteriosclerosis, thrombosis, and vascular biology 37 (6), 1222-1227, 2017
932017
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