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| Wnt addiction of genetically defined cancers reversed by PORCN inhibition B Madan, Z Ke, N Harmston, SY Ho, AO Frois, J Alam, DA Jeyaraj, ... Oncogene 35 (17), 2197-2207, 2016 | 322 | 2016 |
| Recent advances in the synthetic chemistry of bicyclo [1.1. 1] pentane J Kanazawa, M Uchiyama Synlett 30 (01), 1-11, 2019 | 135 | 2019 |
| p53 maintains genomic stability by preventing interference between transcription and replication CQX Yeo, I Alexander, Z Lin, S Lim, OA Aning, R Kumar, ... Cell reports 15 (1), 132-146, 2016 | 94 | 2016 |
| Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP–Resveratrol YL Goh, YT Cui, V Pendharkar, VA Adsool ACS Medicinal Chemistry Letters 8 (5), 516-520, 2017 | 89 | 2017 |
| Compositions and methods for treating viral infections MF Geeta Sharma, Ralf Altmeyer, Vishal Pendharker, Yu Chen US Patent US20100081713A1, 2010 | 86* | 2010 |
| Fragment-based ligand design of novel potent inhibitors of tankyrases EA Larsson, A Jansson, FM Ng, SW Then, R Panicker, B Liu, ... Journal of Medicinal Chemistry 56 (11), 4497-4508, 2013 | 83 | 2013 |
| Combination treatment for myeloproliferative neoplasms using JAK and pan‐class I PI 3K inhibitors ML Choong, C Pecquet, V Pendharkar, CC Diaconu, JWY Yong, SJ Tai, ... Journal of cellular and molecular medicine 17 (11), 1397-1409, 2013 | 68 | 2013 |
| Identification and characterization of a small-molecule inhibitor of Wnt signaling in glioblastoma cells A De Robertis, S Valensin, M Rossi, P Tunici, M Verani, A De Rosa, ... Molecular cancer therapeutics 12 (7), 1180-1189, 2013 | 67 | 2013 |
| Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication B Bailly, CA Richard, G Sharma, L Wang, L Johansen, J Cao, ... Scientific reports 6 (1), 25806, 2016 | 55 | 2016 |
| Discovery and optimization of a porcupine inhibitor AJ Duraiswamy, MA Lee, B Madan, SH Ang, ESW Tan, WWV Cheong, ... Journal of medicinal chemistry 58 (15), 5889-5899, 2015 | 45 | 2015 |
| Reduction of influenza virus-induced lung inflammation and mortality in animals treated with a phosophodisestrase-4 inhibitor and a selective serotonin reuptake inhibitor G Sharma, D Champalal Sharma, L Hwei Fen, M Pathak, N Bethur, ... Emerging Microbes & Infections 2 (1), 1-9, 2013 | 41 | 2013 |
| Optimization of selective mitogen-activated protein kinase interacting kinases 1 and 2 inhibitors for the treatment of blast crisis leukemia H Yang, LR Chennamaneni, MWT Ho, SH Ang, ESW Tan, DA Jeyaraj, ... Journal of Medicinal Chemistry 61 (10), 4348-4369, 2018 | 40 | 2018 |
| Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex W Zhang, SP Neo, J Gunaratne, A Poulsen, L Boping, EH Ong, ... Cellular signalling 27 (3), 436-442, 2015 | 36 | 2015 |
| Scaffold hopping and optimization of maleimide based porcupine inhibitors SY Ho, J Alam, DA Jeyaraj, W Wang, GR Lin, SH Ang, ESW Tan, MA Lee, ... Journal of Medicinal Chemistry 60 (15), 6678-6692, 2017 | 24 | 2017 |
| Discovery of irreversible inhibitors targeting histone methyltransferase, SMYD3 C Huang, SS Liew, GR Lin, A Poulsen, MJY Ang, BCS Chia, SY Chew, ... ACS Medicinal Chemistry Letters 10 (6), 978-984, 2019 | 22 | 2019 |
| Fragment-based drug discovery of potent protein kinase C iota inhibitors J Kwiatkowski, B Liu, DHY Tee, G Chen, NHB Ahmad, YX Wong, ZY Poh, ... Journal of Medicinal Chemistry 61 (10), 4386-4396, 2018 | 22 | 2018 |
| Structure–activity relationship studies of mitogen activated protein kinase interacting kinase (MNK) 1 and 2 and BCR-ABL1 inhibitors targeting chronic myeloid leukemic cells J Cherian, K Nacro, ZY Poh, S Guo, DA Jeyaraj, YX Wong, M Ho, ... Journal of Medicinal Chemistry 59 (7), 3063-3078, 2016 | 18 | 2016 |
| Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria SY Ho, W Wang, FM Ng, YX Wong, ZY Poh, SWE Tan, SH Ang, SS Liew, ... European Journal of Medicinal Chemistry 157, 610-621, 2018 | 13 | 2018 |
| Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors PS Ng, K Foo, S Sim, G Wang, C Huang, LH Tan, A Poulsen, B Liu, ... Bioorganic & Medicinal Chemistry 49, 116437, 2021 | 7 | 2021 |
Thomas H KellerInvestment Partner, Trinity Innovation Bioventures SingaporeBestätigte E-Mail-Adresse bei trinity-fund.com
