Michael Köttgen
Michael Köttgen
University of Freiburg, Department of Medicine IV
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Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
OM Woodward, A Köttgen, J Coresh, E Boerwinkle, WB Guggino, ...
Proceedings of the National Academy of Sciences 106 (25), 10338-10342, 2009
Interaction with podocin facilitates nephrin signaling
TB Huber, M Köttgen, B Schilling, G Walz, T Benzing
Journal of Biological Chemistry 276 (45), 41543-41546, 2001
Primary cilia regulate mTORC1 activity and cell size through Lkb1
C Boehlke, F Kotsis, V Patel, S Braeg, H Voelker, S Bredt, T Beyer, ...
Nature cell biology 12 (11), 1115-1122, 2010
TRPP2 and TRPV4 form a polymodal sensory channel complex
M Köttgen, B Buchholz, MA Garcia-Gonzalez, F Kotsis, X Fu, M Doerken, ...
The Journal of cell biology 182 (3), 437-447, 2008
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
M Köttgen, T Benzing, T Simmen, R Tauber, B Buchholz, S Feliciangeli, ...
The EMBO journal 24 (4), 705-716, 2005
A taste receptor required for the caffeine response in vivo
SJ Moon, M Köttgen, Y Jiao, H Xu, C Montell
Current biology 16 (18), 1812-1817, 2006
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
OM Woodward, DN Tukaye, J Cui, P Greenwell, LM Constantoulakis, ...
Proceedings of the National Academy of Sciences 110 (13), 5223-5228, 2013
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
A Tin, OM Woodward, WHL Kao, CT Liu, X Lu, MA Nalls, D Shriner, ...
Human molecular genetics 20 (20), 4056-4068, 2011
TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum
T Wegierski, D Steffl, C Kopp, R Tauber, B Buchholz, R Nitschke, ...
The EMBO journal 28 (5), 490-499, 2009
Polycystic kidney disease with hyperinsulinemic hypoglycemia caused by a promoter mutation in phosphomannomutase 2
OR Cabezas, SE Flanagan, H Stanescu, E García-Martínez, R Caswell, ...
Journal of the American Society of Nephrology 28 (8), 2529-2539, 2017
Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans
P Schlosser, Y Li, P Sekula, J Raffler, F Grundner-Culemann, M Pietzner, ...
Nature genetics 52 (2), 167-176, 2020
Phosphorylation by casein kinase 2 induces PACS‐1 binding of nephrocystin and targeting to cilia
B Schermer, K Höpker, H Omran, C Ghenoiu, M Fliegauf, A Fekete, ...
The EMBO journal 24 (24), 4415-4424, 2005
ABCG transporters and disease
OM Woodward, A Köttgen, M Köttgen
The FEBS journal 278 (18), 3215-3225, 2011
Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state
J Tosic, GJ Kim, M Pavlovic, CM Schröder, SL Mersiowsky, M Barg, ...
Nature cell biology 21 (12), 1518-1531, 2019
TRPP2 and autosomal dominant polycystic kidney disease
M Köttgen
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1772 (8), 836-850, 2007
P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport
M Köttgen, T Löffler, C Jacobi, R Nitschke, H Pavenstädt, R Schreiber, ...
The Journal of clinical investigation 111 (3), 371-379, 2003
OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum
Y Wang, X Fu, S Gaiser, M Kottgen, A Kramer-Zucker, G Walz, ...
Journal of biological chemistry 282 (50), 36561-36570, 2007
Subcellular localization and trafficking of polycystins
M Köttgen, G Walz
Pflügers Archiv 451, 286-293, 2005
Cilia‐localized LKB 1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney
A Viau, F Bienaimé, K Lukas, AP Todkar, M Knoll, TA Yakulov, A Hofherr, ...
The EMBO journal 37 (15), e98615, 2018
Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-α
T Benzing, M Ko, M Johnson, B Schermer, H Zentgraf, G Walz, E Kim
Journal of Biological Chemistry 277 (36), 32954-32962, 2002
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