| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ... Nature neuroscience 18 (9), 1226-1229, 2015 | 415 | 2015 |
| Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects J Mertens, ACM Paquola, M Ku, E Hatch, L Böhnke, S Ladjevardi, ... Cell stem cell 17 (6), 705-718, 2015 | 353 | 2015 |
| Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder J Mertens, QW Wang, Y Kim, XY Diana, S Pham, B Yang, Y Zheng, ... Nature 527 (7576), 95-99, 2015 | 300 | 2015 |
| Small molecules enable highly efficient neuronal conversion of human fibroblasts J Ladewig, J Mertens, J Kesavan, J Doerr, D Poppe, F Glaue, S Herms, ... Nature methods 9 (6), 575-578, 2012 | 296 | 2012 |
| Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan, D Poppe, J Doerr, ... Nature 480 (7378), 543-546, 2011 | 295 | 2011 |
| Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation X Zheng, L Boyer, M Jin, J Mertens, Y Kim, L Ma, M Hamm, FH Gage, ... Elife 5, e13374, 2016 | 224 | 2016 |
| Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro C Bardy, M Van Den Hurk, T Eames, C Marchand, RV Hernandez, ... Proceedings of the National Academy of Sciences 112 (20), E2725-E2734, 2015 | 198 | 2015 |
| Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience J Mertens, MC Marchetto, C Bardy, FH Gage Nature Reviews Neuroscience 17 (7), 424, 2016 | 181 | 2016 |
| Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ... Neuron 99 (5), 925-940. e7, 2018 | 114 | 2018 |
| Presenilin-1 L166P mutant human pluripotent stem cell–derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation P Koch, IY Tamboli, J Mertens, P Wunderlich, J Ladewig, K Stüber, ... The American journal of pathology 180 (6), 2404-2416, 2012 | 103 | 2012 |
| Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons ST Schafer, ACM Paquola, S Stern, D Gosselin, M Ku, M Pena, TJM Kuret, ... Nature neuroscience 22 (2), 243-255, 2019 | 93 | 2019 |
| Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases J Mertens, D Reid, S Lau, Y Kim, FH Gage Annual review of genetics 52, 271-293, 2018 | 74 | 2018 |
| Generation of functional human serotonergic neurons from fibroblasts KC Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, ... Molecular psychiatry 21 (1), 49-61, 2016 | 72 | 2016 |
| Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells T Toda, JY Hsu, SB Linker, L Hu, ST Schafer, J Mertens, FV Jacinto, ... Cell stem cell 21 (5), 618-634. e7, 2017 | 65 | 2017 |
| APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation J Mertens, K Stüber, P Wunderlich, J Ladewig, JC Kesavan, ... Stem Cell Reports 1 (6), 491-498, 2013 | 63 | 2013 |
| The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample KJ Oedegaard, M Alda, A Anand, OA Andreassen, Y Balaraman, ... BMC psychiatry 16 (1), 129, 2016 | 48 | 2016 |
| Targeting the cytosolic innate immune receptors RIG‐I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma M Glas, C Coch, D Trageser, J DAßLER, M Simon, P Koch, J Mertens, ... Stem Cells 31 (6), 1064-1074, 2013 | 45 | 2013 |
| Mitochondrial aging defects emerge in directly reprogrammed human neurons due to their metabolic profile Y Kim, X Zheng, Z Ansari, MC Bunnell, JR Herdy, L Traxler, H Lee, ... Cell reports 23 (9), 2550-2558, 2018 | 44 | 2018 |
| Embryonic Stem Cell–Based Modeling of Tau Pathology in Human Neurons J Mertens, K Stüber, D Poppe, J Doerr, J Ladewig, O Brüstle, P Koch The American journal of pathology 182 (5), 1769-1779, 2013 | 31 | 2013 |
| Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71 S Mitschka, T Ulas, T Goller, K Schneider, A Egert, J Mertens, O Brüstle, ... Scientific reports 5, 11126, 2015 | 21 | 2015 |
Rusty GageThe Salk InstituteVerified email at salk.edu
