Jerome Mertens
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Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects
J Mertens, ACM Paquola, M Ku, E Hatch, L Böhnke, S Ladjevardi, ...
Cell stem cell 17 (6), 705-718, 2015
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ...
Nature neuroscience 18 (9), 1226-1229, 2015
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
X Zheng, L Boyer, M Jin, J Mertens, Y Kim, L Ma, L Ma, M Hamm, ...
elife 5, e13374, 2016
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder
J Mertens, QW Wang, Y Kim, DX Yu, S Pham, B Yang, Y Zheng, ...
Nature 527 (7576), 95-99, 2015
Small molecules enable highly efficient neuronal conversion of human fibroblasts
J Ladewig, J Mertens, J Kesavan, J Doerr, D Poppe, F Glaue, S Herms, ...
Nature methods 9 (6), 575-578, 2012
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
C Bardy, M Van Den Hurk, T Eames, C Marchand, M Hernandez, ...
Proceedings of the National Academy of Sciences of the United States of …, 2015
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease
P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan, D Poppe, J Doerr, ...
Nature 480 (7378), 543-546, 2011
Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease
B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ...
Neuron 99 (5), 925-940. e7, 2018
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
J Mertens, MC Marchetto, C Bardy, FH Gage
Nature Reviews Neuroscience 17 (7), 424-437, 2016
Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases
J Mertens, D Reid, S Lau, Y Kim, FH Gage
Annual review of genetics 52, 271-293, 2018
Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
ST Schafer, ACM Paquola, S Stern, D Gosselin, M Ku, M Pena, TJM Kuret, ...
Nature neuroscience 22 (2), 243-255, 2019
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetzki, L Böhnke, ...
Cell Stem Cell 28 (9), 1533-1548. e6, 2021
Generation of functional human serotonergic neurons from fibroblasts
KC Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, ...
Molecular psychiatry 21 (1), 49-61, 2016
Presenilin-1 L166P mutant human pluripotent stem cell–derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation
P Koch, IY Tamboli, J Mertens, P Wunderlich, J Ladewig, K Stüber, ...
The American journal of pathology 180 (6), 2404-2416, 2012
Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells
T Toda, JY Hsu, SB Linker, L Hu, ST Schafer, J Mertens, FV Jacinto, ...
Cell stem cell 21 (5), 618-634. e7, 2017
Mitochondrial aging defects emerge in directly reprogrammed human neurons due to their metabolic profile
Y Kim, X Zheng, Z Ansari, MC Bunnell, JR Herdy, L Traxler, H Lee, ...
Cell reports 23 (9), 2550-2558, 2018
APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation
J Mertens, K Stüber, P Wunderlich, J Ladewig, JC Kesavan, ...
Stem Cell Reports 1 (6), 491-498, 2013
The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample
KJ Oedegaard, M Alda, A Anand, OA Andreassen, Y Balaraman, ...
BMC psychiatry 16 (1), 1-15, 2016
Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma
M Glas, C Coch, D Trageser, J Daßler, M Simon, P Koch, J Mertens, ...
Stem Cells 31 (6), 1064-1074, 2013
Next‐generation disease modeling with direct conversion: a new path to old neurons
L Traxler, F Edenhofer, J Mertens
FEBS letters 593 (23), 3316-3337, 2019
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