|Structural insight into catalytic mechanism of PET hydrolase|
X Han, W Liu, JW Huang, J Ma, Y Zheng, TP Ko, L Xu, YS Cheng, ...
Nature communications 8 (1), 2106, 2017
|Multitarget drug discovery for tuberculosis and other infectious diseases|
K Li, LA Schurig-Briccio, X Feng, A Upadhyay, V Pujari, B Lechartier, ...
Journal of medicinal chemistry 57 (7), 3126-3139, 2014
|Enzymatic degradation of plant biomass and synthetic polymers|
CC Chen, L Dai, L Ma, RT Guo
Nature Reviews Chemistry 4 (3), 114-126, 2020
|Bisphosphonates target multiple sites in both cis-and trans-prenyltransferases|
RT Guo, R Cao, PH Liang, TP Ko, TH Chang, MP Hudock, WY Jeng, ...
Proceedings of the National Academy of Sciences 104 (24), 10022-10027, 2007
|Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation|
Y Zhang, R Cao, F Yin, MP Hudock, RT Guo, K Krysiak, S Mukherjee, ...
Journal of the American Chemical Society 131 (14), 5153-5162, 2009
|Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and …|
RT Guo, TP Ko, APC Chen, CJ Kuo, AHJ Wang, PH Liang
Journal of Biological Chemistry 280 (21), 20762-20774, 2005
|Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis|
HM Chu, RT Guo, TW Lin, CC Chou, HL Shr, HL Lai, TY Tang, KJ Cheng, ...
Structure 12 (11), 2015-2024, 2004
|Structural studies reveal the molecular mechanism of PET ase|
CC Chen, X Han, TP Ko, W Liu, RT Guo
The FEBS journal 285 (20), 3717-3723, 2018
|A structural change in butyrophilin upon phosphoantigen binding underlies phosphoantigen-mediated Vγ9Vδ2 T cell activation|
Y Yang, L Li, L Yuan, X Zhou, J Duan, H Xiao, N Cai, S Han, X Ma, W Liu, ...
Immunity 50 (4), 1043-1053. e5, 2019
|Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination|
TH Chang, RT Guo, TP Ko, AHJ Wang, PH Liang
Journal of Biological Chemistry 281 (21), 14991-15000, 2006
|General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis|
CC Chen, X Han, X Li, P Jiang, D Niu, L Ma, W Liu, S Li, Y Qu, H Hu, ...
Nature Catalysis 4 (5), 425-430, 2021
|Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation|
MP Hudock, Y Zhang, RT Guo, R Cao, JH No, PH Liang, TP Ko, ...
Journal of medicinal chemistry 51 (18), 5594-5607, 2008
|Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis|
RT Guo, YE Chong, M Guo, XL Yang
Journal of Biological Chemistry 284 (42), 28968-28976, 2009
|Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis|
WY Jeng, TP Ko, CI Liu, RT Guo, CL Liu, HL Shr, AHJ Wang
Nucleic acids research 36 (5), 1567-1577, 2008
|Squalene synthase as a target for Chagas disease therapeutics|
N Shang, Q Li, TP Ko, HC Chan, J Li, Y Zheng, CH Huang, F Ren, ...
PLoS pathogens 10 (5), e1004114, 2014
|Recognition of double-stranded RNA and regulation of interferon pathway by toll-like receptor 10|
SMY Lee, TF Yip, S Yan, DY Jin, HL Wei, RT Guo, JSM Peiris
Frontiers in Immunology 9, 516, 2018
|Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination|
RT Guo, CJ Kuo, CC Chou, TP Ko, HL Shr, PH Liang, AHJ Wang
Journal of Biological Chemistry 279 (6), 4903-4912, 2004
|Structural analysis of a glycoside hydrolase family 11 xylanase from Neocallimastix patriciarum: insights into the molecular basis of a thermophilic enzyme|
YS Cheng, CC Chen, CH Huang, TP Ko, W Luo, JW Huang, JR Liu, ...
Journal of Biological Chemistry 289 (16), 11020-11028, 2014
|Crystal structures of d-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars|
HC Chan, Y Zhu, Y Hu, TP Ko, CH Huang, F Ren, CC Chen, Y Ma, ...
Protein & cell 3, 123-131, 2012
|Biochemical characterization and structural analysis of a bifunctional cellulase/xylanase from Clostridium thermocellum|
SF Yuan, TH Wu, HL Lee, HY Hsieh, WL Lin, B Yang, CK Chang, Q Li, ...
Journal of Biological Chemistry 290 (9), 5739-5748, 2015