Heiko Runz
Heiko Runz
Biogen Inc., Cambridge, MA, USA
Verified email at - Homepage
Cited by
Cited by
Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo
K Fassbender, M Simons, C Bergmann, M Stroick, D Lütjohann, P Keller, ...
Proceedings of the National Academy of Sciences 98 (10), 5856-5861, 2001
Genomic atlas of the human plasma proteome
BB Sun, JC Maranville, JE Peters, D Stacey, JR Staley, J Blackshaw, ...
Nature 558 (7708), 73-79, 2018
Genome-wide association analysis in primary sclerosing cholangitis
TH Karlsen, A Franke, E Melum, A Kaser, JR Hov, T Balschun, BA Lie, ...
Gastroenterology 138 (3), 1102-1111, 2010
Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
T Miller, M Cudkowicz, PJ Shaw, PM Andersen, N Atassi, RC Bucelli, ...
New England Journal of Medicine 383 (2), 109-119, 2020
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
N Shrine, AL Guyatt, AM Erzurumluoglu, VE Jackson, BD Hobbs, ...
Nature genetics 51 (3), 481-493, 2019
Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells
H Runz, J Rietdorf, I Tomic, M de Bernard, K Beyreuther, R Pepperkok, ...
Journal of Neuroscience 22 (5), 1679-1689, 2002
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
E Melum, A Franke, C Schramm, TJ Weismüller, DN Gotthardt, FA Offner, ...
Nature genetics 43 (1), 17-19, 2011
Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease
K Strauss, C Goebel, H Runz, W Möbius, S Weiss, I Feussner, M Simons, ...
Journal of Biological Chemistry 285 (34), 26279-26288, 2010
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
J Zheng, V Haberland, D Baird, V Walker, PC Haycock, MR Hurle, ...
Nature genetics 52 (10), 1122-1131, 2020
Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
C Yao, G Chen, C Song, J Keefe, M Mendelson, T Huan, BB Sun, A Laser, ...
Nature communications 9 (1), 3268, 2018
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
JD Szustakowski, S Balasubramanian, E Kvikstad, S Khalid, PG Bronson, ...
Nature genetics 53 (7), 942-948, 2021
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
T Folseraas, E Melum, P Rausch, BD Juran, E Ellinghaus, A Shiryaev, ...
Journal of hepatology 57 (2), 366-375, 2012
FinnGen: Unique genetic insights from combining isolated population and national health register data
MI Kurki, J Karjalainen, P Palta, TP Sipilä, K Kristiansson, K Donner, ...
MedRxiv, 2022.03. 03.22271360, 2022
Identification of cholesterol-regulating genes by targeted RNAi screening
F Bartz, L Kern, D Erz, M Zhu, D Gilbert, T Meinhof, U Wirkner, H Erfle, ...
Cell metabolism 10 (1), 63-75, 2009
Genome‐wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
D Ellinghaus, T Folseraas, K Holm, E Ellinghaus, E Melum, T Balschun, ...
Hepatology 58 (3), 1074-1083, 2013
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA van der Spek, MK Bakker, JJFA van Vugt, PJ Hop, ...
Nature genetics 53 (12), 1636-1648, 2021
FinnGen provides genetic insights from a well-phenotyped isolated population
MI Kurki, J Karjalainen, P Palta, TP Sipilä, K Kristiansson, KM Donner, ...
Nature 613 (7944), 508-518, 2023
Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease
T Schwerd, S Pandey, HT Yang, K Bagola, E Jameson, J Jung, ...
Gut 66 (6), 1060-1073, 2017
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
JR Hov, V Keitel, JK Laerdahl, L Spomer, E Ellinghaus, A ElSharawy, ...
PloS one 5 (8), e12403, 2010
Phenome-wide association studies across large population cohorts support drug target validation
D Diogo, C Tian, CS Franklin, M Alanne-Kinnunen, M March, ...
Nature communications 9 (1), 1-13, 2018
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