| Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ... Cell 154 (3), 556-568, 2013 | 398 | 2013 |
| Lactate is a natural suppressor of RLR signaling by targeting MAVS W Zhang, G Wang, ZG Xu, H Tu, F Hu, J Dai, Y Chang, Y Chen, Y Lu, ... Cell 178 (1), 176-189. e15, 2019 | 386 | 2019 |
| The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance F Han, CF Li, Z Cai, X Zhang, G Jin, WN Zhang, C Xu, CY Wang, J Morrow, ... Nature communications 9 (1), 4728, 2018 | 144 | 2018 |
| SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis G Wang, J Long, Y Gao, W Zhang, F Han, C Xu, L Sun, SC Yang, J Lan, ... Nature cell biology 21 (2), 214-225, 2019 | 137 | 2019 |
| A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism Z Cai, JS Zhao, JJ Li, DN Peng, XY Wang, TL Chen, YP Qiu, PP Chen, ... Molecular & Cellular Proteomics 9 (12), 2617-2628, 2010 | 136 | 2010 |
| Phosphorylation of PDHA by AMPK drives TCA cycle to promote cancer metastasis Z Cai, CF Li, F Han, C Liu, A Zhang, CC Hsu, D Peng, X Zhang, G Jin, ... Molecular cell 80 (2), 263-278. e7, 2020 | 134 | 2020 |
| Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress SW Lee, CF Li, G Jin, Z Cai, F Han, CH Chan, WL Yang, BK Li, ... Molecular cell 57 (6), 1022-1033, 2015 | 129 | 2015 |
| K63-linked ubiquitination in kinase activation and cancer G Wang, Y Gao, L Li, G Jin, Z Cai, JI Chao, HK Lin Frontiers in oncology 2, 5, 2012 | 124 | 2012 |
| A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis AH Rezaeian, CF Li, CY Wu, X Zhang, J Delacerda, MJ You, F Han, Z Cai, ... Nature cell biology 19 (1), 38-51, 2017 | 102 | 2017 |
| Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells ZJ Sun, Y Wang, Z Cai, PP Chen, XJ Tong, D Xie British journal of cancer 99 (10), 1656-1667, 2008 | 102 | 2008 |
| The Skp2 pathway: a critical target for cancer therapy Z Cai, A Moten, D Peng, CC Hsu, BS Pan, R Manne, H Li, HK Lin Seminars in cancer biology 67, 16-33, 2020 | 100 | 2020 |
| Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1 G Jin, SW Lee, X Zhang, Z Cai, Y Gao, PC Chou, AH Rezaeian, F Han, ... Molecular cell 58 (6), 989-1000, 2015 | 79 | 2015 |
| Cycles of ubiquitination and deubiquitination critically regulate growth factor–mediated activation of Akt signaling WL Yang, G Jin, CF Li, YS Jeong, A Moten, D Xu, Z Feng, W Chen, Z Cai, ... Science signaling 6 (257), ra3-ra3, 2013 | 74 | 2013 |
| AMPK signaling and its targeting in cancer progression and treatment CC Hsu, D Peng, Z Cai, HK Lin Seminars in cancer biology 85, 52-68, 2022 | 61 | 2022 |
| Cilia loss sensitizes cells to transformation by activating the mevalonate pathway YZ Deng, Z Cai, S Shi, H Jiang, YR Shang, N Ma, JJ Wang, DX Guan, ... Journal of Experimental Medicine 215 (1), 177-195, 2018 | 56 | 2018 |
| Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK CC Hsu, X Zhang, G Wang, W Zhang, Z Cai, BS Pan, H Gu, C Xu, G Jin, ... Molecular cell 81 (18), 3803-3819. e7, 2021 | 42 | 2021 |
| hPCL3s promotes hepatocellular carcinoma metastasis by activating β-catenin signaling Z Cai, ZY Qian, H Jiang, N Ma, Z Li, LY Liu, XX Ren, YR Shang, JJ Wang, ... Cancer research 78 (10), 2536-2549, 2018 | 30 | 2018 |
| SIRPγ-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling C Xu, G Jin, H Wu, W Cui, YH Wang, RK Manne, G Wang, W Zhang, ... The Journal of Clinical Investigation 132 (5), 2022 | 26 | 2022 |
| Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance C Liu, Z Cai, G Jin, D Peng, BS Pan, X Zhang, F Han, X Xu, HK Lin Cell discovery 4 (1), 54, 2018 | 16 | 2018 |
| NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance T Chen, ZG Xu, J Luo, RK Manne, Z Wang, CC Hsu, BS Pan, Z Cai, ... Cell Metabolism 35 (10), 1782-1798. e8, 2023 | 10 | 2023 |
