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Constantinos Demetriades
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Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
C Demetriades, N Doumpas, AA Teleman
Cell 156 (4), 786-799, 2014
4282014
Lysosomal recruitment of TSC2 is a universal response to cellular stress
C Demetriades, M Plescher, AA Teleman
Nature communications 7 (1), 10662, 2016
1662016
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
MT Prentzell, U Rehbein, MC Sandoval, AS De Meulemeester, ...
Cell 184 (3), 655-674. e27, 2021
722021
Genomic analysis reveals a novel nuclear factor-κB (NF-κB)-binding site in Alu-repetitive elements
A Antonaki, C Demetriades, A Polyzos, A Banos, G Vatsellas, MD Lavigne, ...
Journal of Biological Chemistry 286 (44), 38768-38782, 2011
672011
CycD/Cdk4 and discontinuities in Dpp signaling activate TORC1 in the Drosophila wing disc
J Romero-Pozuelo, C Demetriades, P Schroeder, AA Teleman
Developmental cell 42 (4), 376-387. e5, 2017
632017
The multifaceted role of nutrient sensing and mTORC1 signaling in physiology and aging
SA Fernandes, C Demetriades
Frontiers in Aging 2, 38, 2021
462021
Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4α
P Iordanidou, E Aggelidou, C Demetriades, M Hadzopoulou-Cladaras
Journal of Biological Chemistry 280 (23), 21810-21819, 2005
462005
An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
J Nüchel, M Tauber, JL Nolte, M Mörgelin, C Türk, B Eckes, ...
Molecular cell 81 (16), 3275-3293. e12, 2021
452021
A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids
P Gollwitzer, N Grützmacher, S Wilhelm, D Kümmel, C Demetriades
Nature Cell Biology, 2022
322022
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
K Fitzian, A Brückner, L Brohée, R Zech, C Antoni, S Kiontke, R Gasper, ...
Molecular cell 81 (13), 2705-2721. e8, 2021
312021
The LMP1 promoter can be transactivated directly by NF-κB
C Demetriades, G Mosialos
Journal of virology 83 (10), 5269-5277, 2009
312009
TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1
M Plescher, AA Teleman, C Demetriades
Scientific reports 5 (1), 13828, 2015
302015
eIF 4A inactivates TORC 1 in response to amino acid starvation
FF Tsokanos, MA Albert, C Demetriades, K Spirohn, M Boutros, ...
The EMBO journal 35 (10), 1058-1076, 2016
292016
mTORC1 activity negatively regulates human hair follicle growth and pigmentation
T Suzuki, J Chéret, FD Scala, A Akhundlu, J Gherardini, DL Demetrius, ...
EMBO reports, e56574, 2023
122023
Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
W Huang, C Kew, S Fernandes, A Löhrke, L Han, C Demetriades, ...
Nature Aging, 2022
92022
Functional characterization of hepatocyte nuclear factor‐4α dimerization interface mutants
E Aggelidou, P Iordanidou, C Demetriades, O Piltsi, ...
The FEBS journal 273 (9), 1948-1958, 2006
62006
Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
R Nicastro, L Brohée, J Alba, J Nüchel, G Figlia, S Kipschull, P Gollwitzer, ...
Nature Cell Biology 25 (9), 1303-1318, 2023
42023
Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor
F Artoni, N Grützmacher, C Demetriades
Aging Cell, e13888, 2023
32023
Codependencies of mTORC1 signaling and endolysosomal actin structures
A Priya, S Antoine-Bally, AS Macé, P Monteiro, V Sabatet, D Remy, ...
Science Advances 9 (37), eadd9084, 2023
12023
518 Nutrient and stress sensing as novel physiological regulator of human hair pigmentation and greying: Role of mTORC1 activity
T Suzuki, J Chéret, FD Scala, J Gherardini, J O’Sullivan, G Epstein-Kuka, ...
Journal of Investigative Dermatology 142 (12), S270, 2022
1*2022
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