Craig B. Wilen, MD, PhD
Craig B. Wilen, MD, PhD
Associate Professor, Yale University
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Zitiert von
Zitiert von
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
JG Doench, N Fusi, M Sullender, M Hegde, EW Vaimberg, KF Donovan, ...
Nature biotechnology 34 (2), 184-191, 2016
HIV: cell binding and entry
CB Wilen, JC Tilton, RW Doms
Cold Spring Harbor perspectives in medicine 2 (8), a006866, 2012
Neuroinvasion of SARS-CoV-2 in human and mouse brain
E Song, C Zhang, B Israelow, A Lu-Culligan, AV Prado, S Skriabine, P Lu, ...
Journal of Experimental Medicine 218 (3), e20202135, 2021
Phenotypic properties of transmitted founder HIV-1
NF Parrish, F Gao, H Li, EE Giorgi, HJ Barbian, EH Parrish, L Zajic, ...
Proceedings of the National Academy of Sciences 110 (17), 6626-6633, 2013
Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
J Wei, MM Alfajaro, PC DeWeirdt, RE Hanna, WJ Lu-Culligan, WL Cai, ...
Cell 184 (1), 76-91. e13, 2021
Altered virome and bacterial microbiome in human immunodeficiency virus-associated acquired immunodeficiency syndrome
CL Monaco, DB Gootenberg, G Zhao, SA Handley, MS Ghebremichael, ...
Cell host & microbe 19 (3), 311-322, 2016
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
B Israelow, E Song, T Mao, P Lu, A Meir, F Liu, MM Alfajaro, J Wei, ...
Journal of Experimental Medicine 217 (12), e20201241, 2020
Inflammasome activation in infected macrophages drives COVID-19 pathology
E Sefik, R Qu, C Junqueira, E Kaffe, H Mirza, J Zhao, JR Brewer, A Han, ...
Nature 606 (7914), 585-593, 2022
Discovery of a proteinaceous cellular receptor for a norovirus
RC Orchard, CB Wilen, JG Doench, MT Baldridge, BT McCune, YCJ Lee, ...
Science 353 (6302), 933-936, 2016
Molecular mechanisms of HIV entry
CB Wilen, JC Tilton, RW Doms
Viral molecular machines, 223-242, 2011
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes
NG Ravindra, MM Alfajaro, V Gasque, NC Huston, H Wan, K Szigeti-Buck, ...
PLoS biology 19 (3), e3001143, 2021
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
NC Huston, H Wan, MS Strine, RCA Tavares, CB Wilen, AM Pyle
Molecular cell 81 (3), 584-598. e5, 2021
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
S Gandhi, J Klein, AJ Robertson, MA Peña-Hernández, MJ Lin, ...
Nature communications 13 (1), 1547, 2022
Intercellular mitochondria transfer to macrophages regulates white adipose tissue homeostasis and is impaired in obesity
JR Brestoff, CB Wilen, JR Moley, Y Li, W Zou, NP Malvin, MN Rowen, ...
Cell metabolism 33 (2), 270-282. e8, 2021
Tropism for tuft cells determines immune promotion of norovirus pathogenesis
CB Wilen, S Lee, LL Hsieh, RC Orchard, C Desai, BL Hykes Jr, ...
Science 360 (6385), 204-208, 2018
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
CA Didigu, CB Wilen, J Wang, J Duong, AJ Secreto, GA Danet-Desnoyers, ...
Blood, The Journal of the American Society of Hematology 123 (1), 61-69, 2014
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7
NF Parrish, CB Wilen, LB Banks, SS Iyer, JM Pfaff, JF Salazar-Gonzalez, ...
PLoS pathogens 8 (5), e1002686, 2012
Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases
CB Wilen, J Wang, JC Tilton, JC Miller, KA Kim, EJ Rebar, SA Sherrill-Mix, ...
PLoS pathogens 7 (4), e1002020, 2011
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
I Ullah, J Prévost, MS Ladinsky, H Stone, M Lu, SP Anand, ...
Immunity 54 (9), 2143-2158. e15, 2021
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
JCC Hsu, M Laurent-Rolle, JB Pawlak, CB Wilen, P Cresswell
Proceedings of the National Academy of Sciences 118 (24), e2101161118, 2021
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