| Small-molecule proteostasis regulators for protein conformational diseases B Calamini, MC Silva, F Madoux, DM Hutt, S Khanna, MA Chalfant, ... Nature chemical biology 8 (2), 185-196, 2012 | 249 | 2012 |
| Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation L Plate, CB Cooley, JJ Chen, RJ Paxman, CM Gallagher, F Madoux, ... elife 5, e15550, 2016 | 208 | 2016 |
| Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1 Y Wang, DM Lonard, Y Yu, DC Chow, TG Palzkill, J Wang, R Qi, ... Cancer research 74 (5), 1506-1517, 2014 | 172 | 2014 |
| Development of functionally selective, small molecule agonists at kappa opioid receptors L Zhou, KM Lovell, KJ Frankowski, SR Slauson, AM Phillips, JM Streicher, ... Journal of Biological Chemistry 288 (51), 36703-36716, 2013 | 154 | 2013 |
| Advanced development of primary pancreatic organoid tumor models for high-throughput phenotypic drug screening S Hou, H Tiriac, BP Sridharan, L Scampavia, F Madoux, J Seldin, ... SLAS DISCOVERY: Advancing Life Sciences R&D 23 (6), 574-584, 2018 | 139 | 2018 |
| Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases Y Wang, RL Stowe, CE Pinello, G Tian, F Madoux, D Li, LY Zhao, JL Li, ... Chemistry & biology 22 (2), 273-284, 2015 | 100 | 2015 |
| Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle MA Sanders, F Madoux, L Mladenovic, H Zhang, X Ye, M Angrish, ... Cell metabolism 22 (5), 851-860, 2015 | 98 | 2015 |
| Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists M Doghman, J Cazareth, D Douguet, F Madoux, P Hodder, E Lalli The Journal of Clinical Endocrinology & Metabolism 94 (6), 2178-2183, 2009 | 89 | 2009 |
| A 1536-well 3D viability assay to assess the cytotoxic effect of drugs on spheroids F Madoux, A Tanner, M Vessels, L Willetts, S Hou, L Scampavia, ... SLAS DISCOVERY: Advancing Life Sciences R&D 22 (5), 516-524, 2017 | 74 | 2017 |
| Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening F Madoux, X Li, P Chase, G Zastrow, MD Cameron, JJ Conkright, ... Molecular pharmacology 73 (6), 1776-1784, 2008 | 59 | 2008 |
| Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening AB Bialkowska, M Crisp, T Bannister, Y He, S Chowdhury, S Schürer, ... Molecular cancer therapeutics 10 (11), 2043-2051, 2011 | 54 | 2011 |
| Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds J Roth, F Madoux, P Hodder, WR Roush Bioorganic & medicinal chemistry letters 18 (8), 2628-2632, 2008 | 45 | 2008 |
| First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis PB Palde, A Bhaskar, LE Pedró Rosa, F Madoux, P Chase, V Gupta, ... ACS chemical biology 11 (1), 172-184, 2016 | 43 | 2016 |
| Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor F Yan, Y Yu, DC Chow, T Palzkill, F Madoux, P Hodder, P Chase, ... PLoS One 9 (4), e95243, 2014 | 43 | 2014 |
| Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High-Throughput Orthogonal Screening L Pedró-Rosa, FS Buckner, RM Ranade, C Eberhart, F Madoux, ... Journal of biomolecular screening 20 (1), 122-130, 2015 | 37 | 2015 |
| Modulators of STAT transcription factors for the targeted therapy of cancer (STAT3 activators) F Madoux, M Koenig, E Nelson, S Chowdhury, M Cameron, B Mercer, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2010 | 37 | 2010 |
| Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate F Madoux, D Dreymuller, JP Pettiloud, R Santos, C Becker-Pauly, ... Scientific reports 6 (1), 11, 2016 | 36 | 2016 |
| A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype S Kota, S Hou, W Guerrant, F Madoux, S Troutman, V Fernandez-Vega, ... Oncogene 37 (32), 4372-4384, 2018 | 35 | 2018 |
| A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs DM Lewallen, KL Bicker, F Madoux, P Chase, L Anguish, S Coonrod, ... ACS Chemical biology 9 (4), 913-921, 2014 | 33 | 2014 |
| Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation DM Lewallen, A Sreelatha, V Dharmarajan, F Madoux, P Chase, ... ACS chemical biology 9 (2), 433-442, 2014 | 30 | 2014 |
