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Igor Dikiy, PhD
Igor Dikiy, PhD
Protein Biochemistry, Regeneron Pharmaceuticals
Bestätigte E-Mail-Adresse bei regeneron.com
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Zitiert von
Zitiert von
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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear …
MB Fares, N Ait-Bouziad, I Dikiy, MK Mbefo, A Jovičić, A Kiely, JL Holton, ...
Human molecular genetics 23 (17), 4491-4509, 2014
2612014
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
AL Mahul-Mellier, B Fauvet, A Gysbers, I Dikiy, A Oueslati, S Georgeon, ...
Human molecular genetics 23 (11), 2858-2879, 2014
2332014
Folding and misfolding of alpha-synuclein on membranes
I Dikiy, D Eliezer
Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (4), 1013-1018, 2012
2222012
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity
O Khalaf, B Fauvet, A Oueslati, I Dikiy, AL Mahul-Mellier, FS Ruggeri, ...
Journal of Biological Chemistry 289 (32), 21856-21876, 2014
2132014
N-terminal acetylation stabilizes N-terminal helicity in lipid-and micelle-bound α-synuclein and increases its affinity for physiological membranes
I Dikiy, D Eliezer
Journal of Biological Chemistry 289 (6), 3652-3665, 2014
2002014
Characterization of semisynthetic and naturally nα-acetylated α-synuclein in vitro and in intact cells implications for aggregation and cellular properties of α-synuclein
B Fauvet, MB Fares, F Samuel, I Dikiy, A Tandon, D Eliezer, HA Lashuel
Journal of Biological Chemistry 287 (34), 28243-28262, 2012
1902012
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125
M Hejjaoui, S Butterfield, B Fauvet, F Vercruysse, J Cui, I Dikiy, M Prudent, ...
Journal of the American Chemical Society 134 (11), 5196-5210, 2012
1262012
Ligand modulation of sidechain dynamics in a wild-type human GPCR
LD Clark, I Dikiy, K Chapman, KE Rödström, J Aramini, MV LeVine, ...
eLife 6, e28505, 2017
872017
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by …
I Dikiy, B Fauvet, A Jovicic, AL Mahul-Mellier, C Desobry, F El-Turk, ...
ACS chemical biology 11 (9), 2428-2437, 2016
692016
An experimental and computational investigation of spontaneous lasso formation in microcin J25
AL Ferguson, S Zhang, I Dikiy, AZ Panagiotopoulos, PG Debenedetti, ...
Biophysical journal 99 (9), 3056-3065, 2010
612010
STARD4 membrane interactions and sterol binding
DB Iaea, I Dikiy, I Kiburu, D Eliezer, FR Maxfield
Biochemistry 54 (30), 4623-4636, 2015
562015
On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies
L Clark, I Dikiy, DM Rosenbaum, KH Gardner
Journal of biomolecular NMR 71 (4), 203-211, 2018
402018
Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346
I Dikiy, UR Edupuganti, RR Abzalimov, PP Borbat, M Srivastava, JH Freed, ...
Proceedings of the National Academy of Sciences 116 (11), 4963-4972, 2019
212019
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles
DM Kim, I Dikiy, V Upadhyay, DJ Posson, D Eliezer, CM Nimigean
The Journal of General Physiology 148 (2), 119-132, 2016
212016
Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics.
I Dikiy, LD Clark, KH Gardner, DM Rosenbaum
Methods in enzymology 614, 37-65, 2019
92019
1H, 13C, and 15N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4)
I Dikiy, TF Ramlall, D Eliezer
Biomolecular NMR assignments 7 (2), 245-248, 2013
32013
Diversity of function and higher-order structure within HWE sensor histidine kinases
I Dikiy, D Swingle, K Toy, UR Edupuganti, G Rivera-Cancel, KH Gardner
Journal of Biological Chemistry, 104934, 2023
22023
Fragile protein folds: Sequence and environmental factors affecting the equilibrium of two interconverting, stably folded protein conformations
X Xu, I Dikiy, MR Evans, LP Marcelino, KH Gardner
Magnetic Resonance 2 (1), 63-76, 2021
12021
C-Abl Phosphorylates Alpha-synuclein And Regulates Its Degradation, Implication For Alpha-synuclein Clearance And Contribution To The Pathogenesis Of Parkinson's Disease
A Mahul, B Fauvet, A Gysbers, I Dikiy, A Oueslati, S Georgeon, ...
Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1 …, 2014
12014
Nmr methods for antibody higher order structure comparability
I Dikiy, W Matousek
US Patent App. 17/851,845, 2022
2022
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