The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear … MB Fares, N Ait-Bouziad, I Dikiy, MK Mbefo, A Jovičić, A Kiely, JL Holton, ... Human molecular genetics 23 (17), 4491-4509, 2014 | 261 | 2014 |
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease AL Mahul-Mellier, B Fauvet, A Gysbers, I Dikiy, A Oueslati, S Georgeon, ... Human molecular genetics 23 (11), 2858-2879, 2014 | 233 | 2014 |
Folding and misfolding of alpha-synuclein on membranes I Dikiy, D Eliezer Biochimica et Biophysica Acta (BBA)-Biomembranes 1818 (4), 1013-1018, 2012 | 222 | 2012 |
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity O Khalaf, B Fauvet, A Oueslati, I Dikiy, AL Mahul-Mellier, FS Ruggeri, ... Journal of Biological Chemistry 289 (32), 21856-21876, 2014 | 213 | 2014 |
N-terminal acetylation stabilizes N-terminal helicity in lipid-and micelle-bound α-synuclein and increases its affinity for physiological membranes I Dikiy, D Eliezer Journal of Biological Chemistry 289 (6), 3652-3665, 2014 | 200 | 2014 |
Characterization of semisynthetic and naturally nα-acetylated α-synuclein in vitro and in intact cells implications for aggregation and cellular properties of α-synuclein B Fauvet, MB Fares, F Samuel, I Dikiy, A Tandon, D Eliezer, HA Lashuel Journal of Biological Chemistry 287 (34), 28243-28262, 2012 | 190 | 2012 |
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125 M Hejjaoui, S Butterfield, B Fauvet, F Vercruysse, J Cui, I Dikiy, M Prudent, ... Journal of the American Chemical Society 134 (11), 5196-5210, 2012 | 126 | 2012 |
Ligand modulation of sidechain dynamics in a wild-type human GPCR LD Clark, I Dikiy, K Chapman, KE Rödström, J Aramini, MV LeVine, ... eLife 6, e28505, 2017 | 87 | 2017 |
Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by … I Dikiy, B Fauvet, A Jovicic, AL Mahul-Mellier, C Desobry, F El-Turk, ... ACS chemical biology 11 (9), 2428-2437, 2016 | 69 | 2016 |
An experimental and computational investigation of spontaneous lasso formation in microcin J25 AL Ferguson, S Zhang, I Dikiy, AZ Panagiotopoulos, PG Debenedetti, ... Biophysical journal 99 (9), 3056-3065, 2010 | 61 | 2010 |
STARD4 membrane interactions and sterol binding DB Iaea, I Dikiy, I Kiburu, D Eliezer, FR Maxfield Biochemistry 54 (30), 4623-4636, 2015 | 56 | 2015 |
On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies L Clark, I Dikiy, DM Rosenbaum, KH Gardner Journal of biomolecular NMR 71 (4), 203-211, 2018 | 40 | 2018 |
Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346 I Dikiy, UR Edupuganti, RR Abzalimov, PP Borbat, M Srivastava, JH Freed, ... Proceedings of the National Academy of Sciences 116 (11), 4963-4972, 2019 | 21 | 2019 |
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles DM Kim, I Dikiy, V Upadhyay, DJ Posson, D Eliezer, CM Nimigean The Journal of General Physiology 148 (2), 119-132, 2016 | 21 | 2016 |
Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics. I Dikiy, LD Clark, KH Gardner, DM Rosenbaum Methods in enzymology 614, 37-65, 2019 | 9 | 2019 |
1H, 13C, and 15N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4) I Dikiy, TF Ramlall, D Eliezer Biomolecular NMR assignments 7 (2), 245-248, 2013 | 3 | 2013 |
Diversity of function and higher-order structure within HWE sensor histidine kinases I Dikiy, D Swingle, K Toy, UR Edupuganti, G Rivera-Cancel, KH Gardner Journal of Biological Chemistry, 104934, 2023 | 2 | 2023 |
Fragile protein folds: Sequence and environmental factors affecting the equilibrium of two interconverting, stably folded protein conformations X Xu, I Dikiy, MR Evans, LP Marcelino, KH Gardner Magnetic Resonance 2 (1), 63-76, 2021 | 1 | 2021 |
C-Abl Phosphorylates Alpha-synuclein And Regulates Its Degradation, Implication For Alpha-synuclein Clearance And Contribution To The Pathogenesis Of Parkinson's Disease A Mahul, B Fauvet, A Gysbers, I Dikiy, A Oueslati, S Georgeon, ... Qatar Foundation Annual Research Conference Proceedings Volume 2014 Issue 1 …, 2014 | 1 | 2014 |
Nmr methods for antibody higher order structure comparability I Dikiy, W Matousek US Patent App. 17/851,845, 2022 | | 2022 |