Alexander Titz
Alexander Titz
Professor at Saarland University, Group Leader at Helmholtz Institute for Pharmaceutical Research
Bestätigte E-Mail-Adresse bei - Startseite
Zitiert von
Zitiert von
Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
S Wagner, R Sommer, S Hinsberger, C Lu, RW Hartmann, M Empting, ...
Journal of medicinal chemistry 59 (13), 5929-5969, 2016
A safe and convenient method for the preparation of triflyl azide, and its use in diazo transfer reactions to primary amines
A Titz, Z Radic, O Schwardt, B Ernst
Tetrahedron letters 47 (14), 2383-2385, 2006
Caenorhabditis elegans N-glycan core β-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2
A Butschi, A Titz, MA Wälti, V Olieric, K Paschinger, K Nöbauer, X Guo, ...
PLoS Pathog 6 (1), e1000717, 2010
Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas aeruginosa LecB with Distinct Binding Modes
D Hauck, I Joachim, B Frommeyer, A Varrot, B Philipp, HM Möller, ...
ACS chemical biology 8 (8), 1775-1784, 2013
Methylated glycans as conserved targets of animal and fungal innate defense
T Wohlschlager, A Butschi, P Grassi, G Sutov, R Gauss, D Hauck, ...
Proceedings of the National Academy of Sciences 111 (27), E2787-E2796, 2014
Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
R Sommer, S Wagner, K Rox, A Varrot, D Hauck, EC Wamhoff, ...
Journal of the American Chemical Society 140 (7), 2537-2545, 2018
Molecular Basis for Galactosylation of Core Fucose Residues in Invertebrates
A Titz, A Butschi, B Henrissat, YY Fan, T Hennet, E Razzazi-Fazeli, ...
Journal of Biological Chemistry 284 (52), 36223-36233, 2009
Electrochemical synthesis of dimerizing and nondimerizing orthoquinone monoketals
D Deffieux, I Fabre, A Titz, JM Léger, S Quideau
The Journal of organic chemistry 69 (25), 8731-8738, 2004
Covalent lectin inhibition and application in bacterial biofilm imaging
S Wagner, D Hauck, M Hoffmann, R Sommer, I Joachim, R Müller, ...
Angewandte Chemie International Edition 56 (52), 16559-16564, 2017
Parasite glycobiology: a bittersweet symphony
JA Rodrigues, A Acosta-Serrano, M Aebi, MAJ Ferguson, FH Routier, ...
PLoS Pathog 11 (11), e1005169, 2015
New approaches to control infections: anti-biofilm strategies against gram-negative bacteria
R Sommer, I Joachim, S Wagner, A Titz
Chimia International Journal for Chemistry 67 (4), 286-290, 2013
Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
MB Calvert, VR Jumde, A Titz
Beilstein journal of organic chemistry 14 (1), 2607-2617, 2018
Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis
A Torge, S Wagner, PS Chaves, EG Oliveira, SS Guterres, AR Pohlmann, ...
International journal of pharmaceutics 527 (1-2), 92-102, 2017
The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
R Sommer, S Wagner, A Varrot, C Nycholat, A Khaledi, S Häussler, ...
Chemical Science, 2016
A biophysical study with carbohydrate derivatives explains the molecular basis of monosaccharide selectivity of the Pseudomonas aeruginosa lectin LecB
R Sommer, TE Exner, A Titz
PLoS One 9 (11), e112822, 2014
Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa
I Joachim, S Rikker, D Hauck, D Ponader, S Boden, R Sommer, ...
Organic & biomolecular chemistry 14 (33), 7933-7948, 2016
Cinnamide Derivatives of d‐Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa
R Sommer, D Hauck, A Varrot, S Wagner, A Audfray, A Prestel, HM Möller, ...
ChemistryOpen 4 (6), 756-767, 2015
Bisecting galactose as a feature of N-glycans of wild-type and mutant Caenorhabditis elegans
S Yan, L Brecker, C Jin, A Titz, M Dragosits, NG Karlsson, V Jantsch, ...
Molecular & Cellular Proteomics 14 (8), 2111-2125, 2015
Probing the carbohydrate recognition domain of E-selectin: The importance of the acid orientation in sLex mimetics
A Titz, J Patton, M Smiesko, Z Radic, O Schwardt, JL Magnani, B Ernst
Bioorganic & medicinal chemistry 18 (1), 19-27, 2010
Synthesis of Mannoheptose Derivatives and their Evaluation as Inhibitors of the Lectin LecB from the Opportunistic Pathogen Pseudomonas aeruginosa
A Hofmann, R Sommer, D Hauck, J Stifel, I Göttker-Schnetmann, A Titz
Carbohydrate Research, 2015
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