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Donald M. O'Rourke
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Year
IDH mutation impairs histone demethylation and results in a block to cell differentiation
C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ...
Nature 483 (7390), 474-478, 2012
21592012
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
DM O’Rourke, MLP Nasrallah, A Desai, JJ Melenhorst, K Mansfield, ...
Science translational medicine 9 (399), eaaa0984, 2017
15512017
Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial
M Weller, N Butowski, DD Tran, LD Recht, M Lim, H Hirte, L Ashby, ...
The lancet oncology 18 (10), 1373-1385, 2017
9742017
A patient-derived glioblastoma organoid model and biobank recapitulates inter-and intra-tumoral heterogeneity
F Jacob, RD Salinas, DY Zhang, PTT Nguyen, JG Schnoll, SZH Wong, ...
Cell 180 (1), 188-204. e22, 2020
6952020
Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving …
A Maity, N Pore, J Lee, D Solomon, DM O’Rourke
Cancer research 60 (20), 5879-5886, 2000
3522000
Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques
L Macyszyn, H Akbari, JM Pisapia, X Da, M Attiah, V Pigrish, Y Bi, S Pal, ...
Neuro-oncology 18 (3), 417-425, 2015
3082015
Induction of ischemic tolerance following brief focal ischemia in rat brain
SS Glazier, DM O'Rourke, DI Graham, FA Welsh
Journal of Cerebral Blood Flow & Metabolism 14 (4), 545-553, 1994
2971994
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1–independent mechanism
N Pore, S Liu, HK Shu, B Li, D Haas-Kogan, D Stokoe, J Milanini-Mongiat, ...
Molecular biology of the cell 15 (11), 4841-4853, 2004
2932004
CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges
SJ Bagley, AS Desai, GP Linette, CH June, DM O’Rourke
Neuro-oncology 20 (11), 1429-1438, 2018
2782018
Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo
BW Park, HT Zhang, C Wu, A Berezov, X Zhang, R Dua, Q Wang, G Kao, ...
Nature biotechnology 18 (2), 194-198, 2000
2652000
Intraaxial Brain Masses: MR Imaging–based Diagnostic Strategy—Initial Experience1
RN Al-Okaili, J Krejza, JH Woo, RL Wolf, DM O'Rourke, KD Judy, ...
Radiology 243 (2), 539-550, 2007
2592007
Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla
RL Wolf, J Wang, S Wang, ER Melhem, DM O'Rourke, KD Judy, JA Detre
Journal of Magnetic Resonance Imaging: An Official Journal of the …, 2005
2182005
A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma
PY Wen, DA Reardon, TS Armstrong, S Phuphanich, RD Aiken, ...
Clinical Cancer Research 25 (19), 5799-5807, 2019
2172019
Differentiation between glioblastomas, solitary brain metastases, and primary cerebral lymphomas using diffusion tensor and dynamic susceptibility contrast-enhanced MR imaging
S Wang, S Kim, S Chawla, RL Wolf, DE Knipp, A Vossough, DM O'Rourke, ...
American Journal of Neuroradiology 32 (3), 507-514, 2011
2132011
PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating …
N Pore, S Liu, DA Haas-Kogan, DM O’Rourke, A Maity
Cancer research 63 (1), 236-241, 2003
2132003
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Q Wang, Z He, M Huang, T Liu, Y Wang, H Xu, H Duan, P Ma, L Zhang, ...
Nature communications 9 (1), 559, 2018
2102018
Differentiation between glioblastomas and solitary brain metastases using diffusion tensor imaging
S Wang, S Kim, S Chawla, RL Wolf, WG Zhang, DM O'Rourke, KD Judy, ...
Neuroimage 44 (3), 653-660, 2009
1942009
The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors
CJ Wu, DM O'Rourke, GS Feng, GR Johnson, Q Wang, MI Greene
Oncogene 20 (42), 6018-6025, 2001
1852001
Radiomic MRI signature reveals three distinct subtypes of glioblastoma with different clinical and molecular characteristics, offering prognostic value beyond IDH1
S Rathore, H Akbari, M Rozycki, KG Abdullah, MLP Nasrallah, ZA Binder, ...
Scientific reports 8 (1), 5087, 2018
1702018
Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells
A Ayuso-Sacido, JA Moliterno, S Kratovac, GS Kapoor, DM O’Rourke, ...
Journal of neuro-oncology 97, 323-337, 2010
1662010
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