Hong Jiang
Hong Jiang
Principal Investigator, Interdisciplinary Research Center on Biology and Chemistry (IRCBC), Chinese
Verified email at
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Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
J Du, Y Zhou, X Su, JJ Yu, S Khan, H Jiang, J Kim, J Woo, JH Kim, ...
Science 334 (6057), 806-809, 2011
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
H Jiang, S Khan, Y Wang, G Charron, B He, C Sebastian, J Du, R Kim, ...
Nature 496 (7443), 110-113, 2013
Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
H Jiang, X Zhang, X Chen, P Aramsangtienchai, Z Tong, H Lin
Chemical reviews 118 (3), 919-988, 2018
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation
BA Gibson, Y Zhang, H Jiang, KM Hussey, JH Shrimp, H Lin, F Schwede, ...
Science 353 (6294), 45-50, 2016
Investigating the ADP-ribosyltransferase Activity of Sirtuins with NAD Analogues and 32P-NAD
J Du, H Jiang, H Lin
Biochemistry 48 (13), 2878-2890, 2009
PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
YF Yongjia Duan, Aiying Du, Jinge Gu, Gang Duan, Chen Wang, Xinrui Gui ...
Cell Research 29 (3), 233-247, 2019
Clickable NAD analogues for labeling substrate proteins of poly (ADP-ribose) polymerases
H Jiang, JH Kim, KM Frizzell, WL Kraus, H Lin
Journal of the American Chemical Society 132 (27), 9363-9372, 2010
Identifying the functional contribution of the defatty-acylase activity of SIRT6
X Zhang, S Khan, H Jiang, MA Antonyak, X Chen, NA Spiegelman, ...
Nature chemical biology 12 (8), 614-620, 2016
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
Q Liu, R Graeff, IA Kriksunov, H Jiang, B Zhang, N Oppenheimer, H Lin, ...
Journal of Biological Chemistry 284 (40), 27637-27645, 2009
Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small-molecule probe
JH Shrimp, J Hu, M Dong, BS Wang, R MacDonald, H Jiang, Q Hao, ...
Journal of the American Chemical Society 136 (15), 5656-5663, 2014
Structure of a NADH-insensitive hexameric citrate synthase that resists acid inactivation
JA Francois, CM Starks, S Sivanuntakorn, H Jiang, AE Ransome, JW Nam, ...
Biochemistry 45 (45), 13487-13499, 2006
Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38
Q Liu, IA Kriksunov, H Jiang, R Graeff, H Lin, HC Lee, Q Hao
Chemistry & biology 15 (10), 1068-1078, 2008
ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression
QH Meng Yuan, Xiaobing Chen, Yitang Sun, Li Jiang, Zhongni Xia, Kaixiong Ye ...
Acta Pharmaceutica Sinica B 10 (8), 1426-1439, 2020
Lysine fatty acylation promotes lysosomal targeting of TNF-α
H Jiang, X Zhang, H Lin
Scientific Reports 6 (1), 1-10, 2016
ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary
J Congleton, H Jiang, F Malavasi, H Lin, A Yen
Experimental cell research 317 (7), 910-919, 2011
Mechanism-based small molecule probes for labeling CD38 on live cells
H Jiang, J Congleton, Q Liu, P Merchant, F Malavasi, HC Lee, Q Hao, ...
Journal of the American Chemical Society 131 (5), 1658-1659, 2009
Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth
YZ Le Sun, Yu Yan, Heng Lv, Jianlong Li, Zhiyuan Wang, Kun Wang, Lin Wang ...
Cell Chemical Biology, 2021
YBR246W is required for the third step of diphthamide biosynthesis
X Su, W Chen, W Lee, H Jiang, S Zhang, H Lin
Journal of the American Chemical Society 134 (2), 773-776, 2012
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase
X Su, Z Lin, W Chen, H Jiang, S Zhang, H Lin
Proceedings of the National Academy of Sciences 109 (49), 19983-19987, 2012
Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
YZ Lu Yang, Zaijun Ma, Han Wang, Kongyan Niu, Ye Cao, Le Sun, Yang Geng, Bo ...
Nat Communications 10 (1), 2191, 2019
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