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Mark D Wrona
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MSE with mass defect filtering for in vitro and in vivo metabolite identification
KP Bateman, J Castro‐Perez, M Wrona, JP Shockcor, K Yu, R Oballa, ...
Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2007
3072007
‘All‐in‐one’analysis for metabolite identification using liquid chromatography/hybrid quadrupole time‐of‐flight mass spectrometry with collision energy switching
M Wrona, T Mauriala, KP Bateman, RJ Mortishire‐Smith, D O'Connor
Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2005
2022005
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
B Côté, JD Burch, E Asante-Appiah, C Bayly, L Bédard, M Blouin, ...
Bioorganic & medicinal chemistry letters 24 (3), 917-922, 2014
952014
Solution NMR structure and X-ray absorption analysis of the C-terminal zinc-binding domain of the SecA ATPase
BR Dempsey, M Wrona, JM Moulin, GB Gloor, F Jalilehvand, G Lajoie, ...
Biochemistry 43 (29), 9361-9371, 2004
422004
Discovery of 4-{1-[({1-[4-(trifluoromethyl) benzyl]-1H-indol-7-yl} carbonyl) amino] cyclopropyl} benzoic acid (MF-766), a highly potent and selective EP4 antagonist for …
J Colucci, M Boyd, C Berthelette, JF Chiasson, Z Wang, Y Ducharme, ...
Bioorganic & medicinal chemistry letters 20 (12), 3760-3763, 2010
382010
A novel series of potent and selective EP4 receptor ligands: facile modulation of agonism and antagonism
MJ Boyd, C Berthelette, JF Chiasson, P Clark, J Colucci, D Denis, Y Han, ...
Bioorganic & medicinal chemistry letters 21 (1), 484-487, 2011
342011
The discovery of 4-{1-[({2, 5-dimethyl-4-[4-(trifluoromethyl) benzyl]-3-thienyl} carbonyl) amino] cyclopropyl} benzoic acid (MK-2894), a potent and selective prostaglandin E2 …
M Blouin, Y Han, J Burch, J Farand, C Mellon, M Gaudreault, M Wrona, ...
Journal of medicinal chemistry 53 (5), 2227-2238, 2010
332010
Chemical profiling of ginseng species and ginseng herbal products using UPLC/QTOF-MS
J Yuk, DN Patel, G Isaac, K Smith, M Wrona, HJ Olivos, K Yu
Journal of the Brazilian Chemical Society 27, 1476-1483, 2016
222016
Novel interconnections in lipid metabolism revealed by overexpression of sphingomyelin synthase-1
GM Deevska, PP Dotson, AA Karakashian, G Isaac, M Wrona, SB Kelly, ...
Journal of Biological Chemistry 292 (12), 5110-5122, 2017
212017
Integration of microfluidic LC with HRMS for the analysis of analytes in biofluids: past, present and future
PD Rainville, JI Langridge, MD Wrona, ID Wilson, RS Plumb
Bioanalysis 7 (11), 1397-1411, 2015
192015
Structure–activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor
JD Burch, M Belley, R Fortin, D Deschênes, M Girard, J Colucci, J Farand, ...
Bioorganic & medicinal chemistry letters 18 (6), 2048-2054, 2008
192008
Metabolic profiling of hoodia, chamomile, Terminalia species and evaluation of commercial preparations using ultrahigh-performance liquid chromatography quadrupole-time-of …
B Avula, YH Wang, G Isaac, J Yuk, M Wrona, K Yu, IA Khan
Planta Medica 83 (16), 1297-1308, 2017
152017
Synthesis of histamine dihydrochloride
WL Yeh, C Antczak, JD Mcgolrick, MJ Roth, M Wrona
US Patent 6,620,942, 2003
142003
Development and application of sub‐2‐μm particle CO2‐based chromatography coupled to mass spectrometry for comprehensive analysis of lipids in cottonseed extracts
C Salazar, MD Jones, D Sturtevant, PJ Horn, J Crossley, K Zaman, ...
Rapid Communications in Mass Spectrometry 31 (7), 591-605, 2017
132017
Development of an UPLC/MS–MS method for quantification of intact IGF-I from human serum
NN Tanna, ME Lame, M Wrona
Bioanalysis 12 (1), 53-65, 2020
122020
Characterization of (16R) and (16S)-hydroxyroquefortine C; diastereomeric metabolites from Penicillium crustosum DAOM 215343
LA Trimble, MW Sumarah, BA Blackwell, MD Wrona, JD Miller
Tetrahedron Letters 53 (8), 956-958, 2012
122012
Metabolite identification using an ion mobility enhanced data‐independent acquisition strategy and automated data processing
T Radchenko, CJ Kochansky, M Cancilla, MD Wrona, RJ Mortishire‐Smith, ...
Rapid Communications in Mass Spectrometry 34 (12), e8792, 2020
112020
Microflow UPLC and high-resolution MS as a sensitive and robust platform for quantitation of intact peptide hormones
Z Chen, YW Alelyunas, MD Wrona, JR Kehler, ME Szapacs, CA Evans
Bioanalysis 11 (13), 1275-1289, 2019
112019
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor
JD Burch, J Farand, J Colucci, C Sturino, Y Ducharme, RW Friesen, ...
Bioorganic & medicinal chemistry letters 21 (3), 1041-1046, 2011
112011
An HS-MRM assay for the quantification of host-cell proteins in protein biopharmaceuticals by liquid chromatography ion mobility QTOF mass spectrometry
C Doneanu, J Fang, Y Alelyunas, YQ Yu, M Wrona, W Chen
JoVE (Journal of Visualized Experiments), e55325, 2018
102018
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Articles 1–20