Nicolas Doucet
Nicolas Doucet
Centre Armand-Frappier Santé Biotechnologie, INRS, Université du Québec
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Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design
RA Chica, N Doucet, JN Pelletier
Current opinion in biotechnology 16 (4), 378-384, 2005
The end of an old hypothesis: the Pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids
CE Dulcey, V Dekimpe, DA Fauvelle, S Milot, MC Groleau, N Doucet, ...
Chemistry & biology 20 (12), 1481-1491, 2013
The flexibility of a distant loop modulates active site motion and product release in ribonuclease A
N Doucet, ED Watt, JP Loria
Biochemistry 48 (30), 7160-7168, 2009
Incorporation of manganese complexes into xylanase: new artificial metalloenzymes for enantioselective epoxidation
M Allard, C Dupont, V Muñoz Robles, N Doucet, A Lledós, JD Maréchal, ...
ChemBioChem 13 (2), 240-251, 2012
Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 β-lactamase
N Doucet, PY De Wals, JN Pelletier
Journal of Biological Chemistry 279 (44), 46295-46303, 2004
Short-chain flavor ester synthesis in organic media by an E. coli whole-cell biocatalyst expressing a newly characterized heterologous lipase
G Brault, F Shareck, Y Hurtubise, F Lépine, N Doucet
PLoS One 9 (3), e91872, 2014
Isolation and characterization of EstC, a new cold-active esterase from Streptomyces coelicolor A3 (2)
G Brault, F Shareck, Y Hurtubise, F Lépine, N Doucet
PloS one 7 (3), e32041, 2012
Combining chitinase C and N-acetylhexosaminidase from Streptomyces coelicolor A3 (2) provides an efficient way to synthesize N-acetylglucosamine from crystalline chitin
N Nguyen-Thi, N Doucet
Journal of biotechnology 220, 25-32, 2016
NMR investigation of Tyr105 mutants in TEM-1 β-lactamase: dynamics are correlated with function
N Doucet, PY Savard, JN Pelletier
Journal of Biological Chemistry 282 (29), 21448-21459, 2007
Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells
AA Grosset, M Labrie, D Gagné, MC Vladoiu, L Gaboury, N Doucet, ...
BMC cancer 14 (1), 1-10, 2014
Conservation of flexible residue clusters among structural and functional enzyme homologues
D Gagné, LA Charest, S Morin, EL Kovrigin, N Doucet
Journal Of Biological Chemistry 287 (53), 44289-44300, 2012
Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase A
N Doucet, G Khirich, EL Kovrigin, JP Loria
Biochemistry 50 (10), 1723-1730, 2011
Structural and functional importance of local and global conformational fluctuations in the RN ase A superfamily
D Gagné, N Doucet
The FEBS journal 280 (22), 5596-5607, 2013
Maintenance of native-like protein dynamics may not be required for engineering functional proteins
SMC Gobeil, CM Clouthier, J Park, D Gagné, AM Berghuis, N Doucet, ...
Chemistry & biology 21 (10), 1330-1340, 2014
Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide
ND Doan, M Létourneau, D Vaudry, N Doucet, B Folch, H Vaudry, ...
Journal of controlled release 163 (2), 256-265, 2012
Simulated annealing exploration of an active‐site tyrosine in TEM‐1β‐lactamase suggests the existence of alternate conformations
N Doucet, JN Pelletier
Proteins: Structure, Function, and Bioinformatics 69 (2), 340-348, 2007
High tolerance to simultaneous active‐site mutations in TEM‐1 β‐lactamase: Distinct mutational paths provide more generalized β‐lactam recognition
PY De Wals, N Doucet, JN Pelletier
Protein science 18 (1), 147-160, 2009
Perturbation of the conformational dynamics of an active-site loop alters enzyme activity
D Gagné, RL French, C Narayanan, M Simonović, PK Agarwal, N Doucet
Structure 23 (12), 2256-2266, 2015
Conservation of dynamics associated with biological function in an enzyme superfamily
C Narayanan, DN Bernard, K Bafna, D Gagné, CS Chennubhotla, ...
Structure 26 (3), 426-436. e3, 2018
Role of conformational motions in enzyme function: selected methodologies and case studies
C Narayanan, DN Bernard, N Doucet
Catalysts 6 (6), 81, 2016
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