An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome T Bürckstümmer, C Baumann, S Blüml, E Dixit, G Dürnberger, H Jahn, ... Nature immunology 10 (3), 266-272, 2009 | 1278 | 2009 |
IFIT1 is an antiviral protein that recognizes 5 [prime]-triphosphate RNA A Pichlmair, C Lassnig, CA Eberle, MW Górna, CL Baumann, TR Burkard, ... Nature immunology 12 (7), 624-630, 2011 | 602 | 2011 |
An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells T Bürckstümmer, KL Bennett, A Preradovic, G Schütze, O Hantschel, ... Nature methods 3 (12), 1013-1019, 2006 | 485 | 2006 |
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response D Soulat, T Bürckstümmer, S Westermayer, A Goncalves, A Bauch, ... The EMBO journal 27 (15), 2135-2146, 2008 | 373 | 2008 |
The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib O Hantschel, U Rix, U Schmidt, T Bürckstümmer, M Kneidinger, G Schütze, ... Proceedings of the National Academy of Sciences 104 (33), 13283-13288, 2007 | 353 | 2007 |
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line P Essletzbichler, T Konopka, F Santoro, D Chen, BV Gapp, R Kralovics, ... Genome Research, gr. 177220.114, 2014 | 331 | 2014 |
Viral immune modulators perturb the human molecular network by common and unique strategies A Pichlmair, K Kandasamy, G Alvisi, O Mulhern, R Sacco, M Habjan, ... Nature, 2012 | 285 | 2012 |
Biological plasticity rescues target activity in CRISPR knock outs AH Smits, F Ziebell, G Joberty, N Zinn, WF Mueller, S Clauder-Münster, ... Nature methods 16 (11), 1087-1093, 2019 | 231 | 2019 |
A generic strategy for CRISPR-Cas9-mediated gene tagging DH Lackner, A Carré, PM Guzzardo, C Banning, R Mangena, T Henley, ... Nature Communications 6, 2015 | 222 | 2015 |
SAMHD1 is a nucleic‐acid binding protein that is mislocalized due to aicardi–goutières syndrome‐associated mutations A Goncalves, E Karayel, GI Rice, KL Bennett, YJ Crow, G Superti‐Furga, ... Human Mutation, 2012 | 159 | 2012 |
Functional dissection of the TBK1 molecular network A Goncalves, T Bürckstümmer, E Dixit, R Scheicher, MW Górna, E Karayel, ... PloS one 6 (9), e23971, 2011 | 144 | 2011 |
A reversible gene trap collection empowers haploid genetics in human cells T Bürckstümmer, C Banning, P Hainzl, R Schobesberger, C Kerzendorfer, ... Nature methods 10 (10), 965-971, 2013 | 117 | 2013 |
Initial characterization of the human central proteome TR Burkard, M Planyavsky, I Kaupe, FP Breitwieser, T Bürckstümmer, ... BMC systems biology 5 (1), 17, 2011 | 106 | 2011 |
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor R Seifert, K Wenzel-Seifert, T Bürckstümmer, HH Pertz, W Schunack, ... Journal of Pharmacology and Experimental Therapeutics 305 (3), 1104-1115, 2003 | 104 | 2003 |
Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication T Bürckstümmer, M Kriegs, J Lupberger, EK Pauli, S Schmittel, E Hildt FEBS letters 580 (2), 575-580, 2006 | 92 | 2006 |
Distinct interaction of human and guinea pig histamine H2-receptor with guanidine-type agonists MT Kelley, T Bürckstümmer, K Wenzel-Seifert, S Dove, A Buschauer, ... Molecular Pharmacology 60 (6), 1210-1225, 2001 | 86 | 2001 |
The human histamine H2‐receptor couples more efficiently to Sf9 insect cell Gs‐proteins than to insect cell Gq‐proteins: limitations of Sf9 cells for the analysis of receptor … C Houston, K Wenzel‐Seifert, T Bürckstümmer, R Seifert Journal of neurochemistry 80 (4), 678-696, 2002 | 71 | 2002 |
The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo M Kriegs, T Bürckstümmer, K Himmelsbach, M Bruns, L Frelin, G Ahlén, ... Journal of Biological Chemistry 284 (41), 28343-28351, 2009 | 61 | 2009 |
The TLR‐independent DNA recognition pathway in murine macrophages: Ligand features and molecular signature E Karayel, T Bürckstümmer, M Bilban, G Dürnberger, S Weitzer, ... European journal of immunology 39 (7), 1929-1936, 2009 | 41 | 2009 |
Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology S Lekomtsev, S Aligianni, A Lapao, T Bürckstümmer BMC Genomics 17 (1), 739, 2016 | 29 | 2016 |