| Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection P Hou, S Chen, S Wang, X Yu, Y Chen, M Jiang, K Zhuang, W Ho, W Hou, ... Scientific reports 5 (1), 15577, 2015 | 254 | 2015 |
| Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy Q Xiao, D Guo, S Chen Frontiers in cellular and infection microbiology 9, 69, 2019 | 191 | 2019 |
| The tumor suppressor PTEN has a critical role in antiviral innate immunity S Li, M Zhu, R Pan, T Fang, YY Cao, S Chen, X Zhao, CQ Lei, L Guo, ... Nature immunology 17 (3), 241-249, 2016 | 171 | 2016 |
| Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4+ T cells from HIV-1 infection Z Liu, S Chen, X Jin, Q Wang, K Yang, C Li, Q Xiao, P Hou, S Liu, S Wu, ... Cell & bioscience 7, 1-15, 2017 | 161 | 2017 |
| Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome X Liu, R Hao, S Chen, D Guo, Y Chen Journal of General Virology 96 (8), 2252-2261, 2015 | 160 | 2015 |
| SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways S Chen, S Bonifati, Z Qin, C St. Gelais, KM Kodigepalli, BS Barrett, ... Proceedings of the National Academy of Sciences 115 (16), E3798-E3807, 2018 | 122 | 2018 |
| A genome-wide CRISPR screen identifies genes critical for resistance to FLT3 inhibitor AC220 P Hou, C Wu, Y Wang, R Qi, D Bhavanasi, Z Zuo, C Dos Santos, S Chen, ... Cancer research 77 (16), 4402-4413, 2017 | 89 | 2017 |
| A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection P Hou, K Yang, P Jia, L Liu, Y Lin, Z Li, J Li, S Chen, S Guo, JA Pan, J Wu, ... Cell research 31 (1), 62-79, 2021 | 63 | 2021 |
| Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection Q Wang, S Liu, Z Liu, Z Ke, C Li, X Yu, S Chen, D Guo Virus research 250, 21-30, 2018 | 55 | 2018 |
| Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection Q Wang, S Chen, Q Xiao, Z Liu, S Liu, P Hou, L Zhou, W Hou, W Ho, C Li, ... Retrovirology 14, 1-12, 2017 | 51 | 2017 |
| CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T … Q Xiao, S Chen, Q Wang, Z Liu, S Liu, H Deng, W Hou, D Wu, Y Xiong, ... Retrovirology 16, 1-17, 2019 | 50 | 2019 |
| N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages S Chen, S Kumar, CE Espada, N Tirumuru, MP Cahill, L Hu, C He, L Wu PLoS pathogens 17 (3), e1009421, 2021 | 49 | 2021 |
| CRISPR-Cas targeting of host genes as an antiviral strategy S Chen, X Yu, D Guo Viruses 10 (1), 40, 2018 | 46 | 2018 |
| SAMHD1 suppression of antiviral immune responses S Chen, S Bonifati, Z Qin, CS Gelais, L Wu Trends in microbiology 27 (3), 254-267, 2019 | 45 | 2019 |
| HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies S Liu, Q Wang, X Yu, Y Li, Y Guo, Z Liu, F Sun, W Hou, C Li, L Wu, D Guo, ... Scientific Reports 8 (1), 1-11, 2018 | 39 | 2018 |
| CRISPR/Cas9-mediated deletion of miR-146a enhances antiviral response in HIV-1 infected cells Y Teng, M Luo, T Yu, L Chen, Q Huang, S Chen, L Xie, Y Zeng, F Luo, ... Genes & Immunity 20 (4), 327-337, 2019 | 33 | 2019 |
| Genome editing of CCR5 by AsCpf1 renders CD4+T cells resistance to HIV-1 infection Z Liu, J Liang, S Chen, K Wang, X Liu, B Liu, Y Xia, M Guo, X Zhang, ... Cell & bioscience 10, 1-13, 2020 | 26 | 2020 |
| ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer K Chen, G Yu, K Gumireddy, A Li, W Yao, L Gao, S Chen, J Hao, J Wang, ... Oncotarget 6 (9), 6959, 2015 | 25 | 2015 |
| The sumoylation of zinc‐fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity S Chen, X Yu, Q Lei, L Ma, D Guo Journal of cellular biochemistry 114 (10), 2323-2333, 2013 | 23 | 2013 |
| TCTP increases stability of hypoxia‐inducible factor 1α by interaction with and degradation of the tumour suppressor VHL K Chen, S Chen, C Huang, H Cheng, R Zhou Biology of the Cell 105 (5), 208-218, 2013 | 23 | 2013 |
