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Frederick L. Locke
Frederick L. Locke
Chair, Department of Blood and Marrow Transplant and Cellular Immunotherapy
Bestätigte E-Mail-Adresse bei moffitt.org - Startseite
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Zitiert von
Zitiert von
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Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma
SS Neelapu, FL Locke, NL Bartlett, LJ Lekakis, DB Miklos, CA Jacobson, ...
New England Journal of Medicine 377 (26), 2531-2544, 2017
47332017
ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells
DW Lee, BD Santomasso, FL Locke, A Ghobadi, CJ Turtle, JN Brudno, ...
Biology of blood and marrow transplantation 25 (4), 625-638, 2019
21312019
Chimeric antigen receptor T-cell therapy—assessment and management of toxicities
SS Neelapu, S Tummala, P Kebriaei, W Wierda, C Gutierrez, FL Locke, ...
Nature reviews Clinical oncology 15 (1), 47-62, 2018
20392018
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial
FL Locke, A Ghobadi, CA Jacobson, DB Miklos, LJ Lekakis, OO Oluwole, ...
The lancet oncology 20 (1), 31-42, 2019
18492019
KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma
M Wang, J Munoz, A Goy, FL Locke, CA Jacobson, BT Hill, ...
New England journal of medicine 382 (14), 1331-1342, 2020
13422020
Axicabtagene ciloleucel as second-line therapy for large B-cell lymphoma
FL Locke, DB Miklos, CA Jacobson, MA Perales, MJ Kersten, OO Oluwole, ...
New England Journal of Medicine 386 (7), 640-654, 2022
7752022
Phase 1 results of ZUMA-1: a multicenter study of KTE-C19 anti-CD19 CAR T cell therapy in refractory aggressive lymphoma
FL Locke, SS Neelapu, NL Bartlett, T Siddiqi, JC Chavez, CM Hosing, ...
Molecular Therapy 25 (1), 285-295, 2017
6562017
Standard-of-care axicabtagene ciloleucel for relapsed or refractory large B-cell lymphoma: results from the US Lymphoma CAR T Consortium
LJ Nastoupil, MD Jain, L Feng, JY Spiegel, A Ghobadi, Y Lin, S Dahiya, ...
Journal of Clinical Oncology 38 (27), 3119, 2020
5812020
Management of immunotherapy-related toxicities, version 1.2019, NCCN clinical practice guidelines in oncology
JA Thompson, BJ Schneider, J Brahmer, S Andrews, P Armand, S Bhatia, ...
Journal of the National Comprehensive Cancer Network 17 (3), 255-289, 2019
4872019
Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma
MC Pasquini, ZH Hu, K Curran, T Laetsch, F Locke, R Rouce, ...
Blood advances 4 (21), 5414-5424, 2020
3282020
Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma
FL Locke, JM Rossi, SS Neelapu, CA Jacobson, DB Miklos, A Ghobadi, ...
Blood advances 4 (19), 4898-4911, 2020
2722020
Cardiovascular events among adults treated with chimeric antigen receptor T-cells (CAR-T)
RM Alvi, MJ Frigault, MG Fradley, MD Jain, SS Mahmood, M Awadalla, ...
Journal of the American College of Cardiology 74 (25), 3099-3108, 2019
2612019
CAR-HEMATOTOX: a model for CAR T-cell–related hematologic toxicity in relapsed/refractory large B-cell lymphoma
K Rejeski, A Perez, P Sesques, E Hoster, C Berger, L Jentzsch, ...
Blood, The Journal of the American Society of Hematology 138 (24), 2499-2513, 2021
2132021
Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit'ALL'
SS Neelapu, S Tummala, P Kebriaei, W Wierda, FL Locke, Y Lin, N Jain, ...
Nature reviews Clinical oncology 15 (4), 218-218, 2018
2032018
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events
MV Maus, S Alexander, MR Bishop, JN Brudno, C Callahan, ML Davila, ...
Journal for immunotherapy of cancer 8 (2), 2020
1792020
Immune reconstitution and associated infections following axicabtagene ciloleucel in relapsed or refractory large B-cell lymphoma
JM Logue, E Zucchetti, CA Bachmeier, GS Krivenko, V Larson, D Ninh, ...
Haematologica 106 (4), 978, 2021
1722021
Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma
MD Jain, H Zhao, X Wang, R Atkins, M Menges, K Reid, K Spitler, ...
Blood, The Journal of the American Society of Hematology 137 (19), 2621-2633, 2021
1632021
High metabolic tumor volume is associated with decreased efficacy of axicabtagene ciloleucel in large B-cell lymphoma
EA Dean, RS Mhaskar, H Lu, MS Mousa, GS Krivenko, A Lazaryan, ...
Blood Advances 4 (14), 3268-3276, 2020
1582020
Preliminary results of prophylactic tocilizumab after axicabtageneciloleucel (axi-cel; KTE-C19) treatment for patients with refractory, aggressive non-Hodgkin lymphoma (NHL)
FL Locke, SS Neelapu, NL Bartlett, LJ Lekakis, CA Jacobson, ...
Blood 130, 1547, 2017
1572017
Efficacy and safety of CD19‐directed CAR‐T cell therapies in patients with relapsed/refractory aggressive B‐cell lymphomas: Observations from the JULIET, ZUMA‐1, and TRANSCEND …
JR Westin, MJ Kersten, G Salles, JS Abramson, SJ Schuster, FL Locke, ...
American journal of hematology 96 (10), 1295-1312, 2021
1312021
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