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Simon R Lord
Simon R Lord
Verified email at oncology.ox.ac.uk
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Year
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation
K Bensaad, E Favaro, CA Lewis, B Peck, S Lord, JM Collins, KE Pinnick, ...
Cell reports 9 (1), 349-365, 2014
5972014
Trastuzumab duocarmazine in locally advanced and metastatic solid tumours and HER2-expressing breast cancer: a phase 1 dose-escalation and dose-expansion study
U Banerji, CML van Herpen, C Saura, F Thistlethwaite, S Lord, V Moreno, ...
The Lancet Oncology 20 (8), 1124-1135, 2019
4032019
Imaging tumour hypoxia with positron emission tomography
IN Fleming, R Manavaki, PJ Blower, C West, KJ Williams, AL Harris, ...
British journal of cancer 112 (2), 238-250, 2015
3542015
Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer
SR Lord, WC Cheng, D Liu, E Gaude, S Haider, T Metcalf, N Patel, ...
Cell metabolism 28 (5), 679-688. e4, 2018
1182018
Gene expression and hypoxia in breast cancer
E Favaro, S Lord, AL Harris, FM Buffa
Genome medicine 3, 1-12, 2011
1132011
Efficacy of reduced-intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal …
PS Hall, D Swinson, DA Cairns, JS Waters, R Petty, C Allmark, S Ruddock, ...
JAMA oncology 7 (6), 869-877, 2021
1052021
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
M Morotti, E Bridges, A Valli, H Choudhry, H Sheldon, S Wigfield, N Gray, ...
Proceedings of the National Academy of Sciences 116 (25), 12452-12461, 2019
1052019
A phase I expansion cohorts study of SYD985 in heavily pretreated patients with HER2-positive or HER2-low metastatic breast cancer.
C Saura, F Thistlethwaite, U Banerji, S Lord, V Moreno, I MacPherson, ...
Journal of Clinical Oncology 36 (15_suppl), 1014-1014, 2018
702018
The current status of risk-stratified breast screening
AK Clift, D Dodwell, S Lord, S Petrou, SM Brady, GS Collins, ...
British journal of cancer 126 (4), 533-550, 2022
612022
BEGONIA: phase 1b/2 study of durvalumab (D) combinations in locally advanced/metastatic triple-negative breast cancer (TNBC)—initial results from arm 1, d+ paclitaxel (P), and …
P Schmid, SA Im, A Armstrong, YH Park, WP Chung, Z Nowecki, S Lord, ...
Journal of Clinical Oncology 39 (15_suppl), 1023-1023, 2021
552021
Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours
GI Shapiro, R Wesolowski, C Devoe, S Lord, J Pollard, BS Hendriks, ...
British journal of cancer 125 (4), 520-527, 2021
472021
A randomised phase II trial and feasibility study of palliative chemotherapy in frail or elderly patients with advanced gastroesophageal cancer (321GO)
PS Hall, SR Lord, M Collinson, H Marshall, M Jones, C Lowe, H Howard, ...
British journal of cancer 116 (4), 472-478, 2017
452017
Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications
J Greene, A Segaran, S Lord
Seminars in Cancer Biology, 2022
442022
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
SR Lord, AL Harris
British Journal of Cancer 128 (6), 958-966, 2023
332023
Radiogenomics monitoring in breast cancer identifies metabolism and immune checkpoints as early actionable mechanisms of resistance to anti-angiogenic treatment
S Mehta, NP Hughes, S Li, A Jubb, R Adams, S Lord, L Koumakis, ...
EBioMedicine 10, 109-116, 2016
332016
Transcriptomic analysis of human primary breast cancer identifies fatty acid oxidation as a target for metformin
SR Lord, JM Collins, WC Cheng, S Haider, S Wigfield, E Gaude, ...
British journal of cancer 122 (2), 258-265, 2020
322020
First-in-human phase I study of MP0250, a first-in-class DARPin drug candidate targeting VEGF and HGF, in patients with advanced solid tumors
RD Baird, C Linossi, M Middleton, S Lord, A Harris, J Rodón, C Zitt, ...
Journal of Clinical Oncology 39 (2), 145, 2021
242021
Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation. Cell Rep. 2014; 9 (1): 349–65
K Bensaad, E Favaro, CA Lewis, B Peck, S Lord, JM Collins, KE Pinnick, ...
Epub 2014/09/30. https://doi. org/10.1016/j. celrep. 2014.08. 056 PMID: 25263561, 0
21
Obesity: A perfect storm for carcinogenesis
BHL Harris, VM Macaulay, DA Harris, P Klenerman, F Karpe, SR Lord, ...
Cancer and Metastasis Reviews 41 (3), 491-515, 2022
202022
Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer
ML Telli, SM Tolaney, GI Shapiro, M Middleton, SR Lord, HT Arkenau, ...
NPJ Breast Cancer 8 (1), 45, 2022
182022
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