Alex S. Holehouse
Alex S. Holehouse
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Cited by
A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins
J Wang, JM Choi, AS Holehouse, HO Lee, X Zhang, M Jahnel, ...
Cell 174 (3), 688-699. e16, 2018
Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein
CW Pak, M Kosno, AS Holehouse, SB Padrick, A Mittal, R Ali, AA Yunus, ...
Molecular Cell 63 (1), 72-85, 2016
Phase separation of a yeast prion protein promotes cellular fitness
TM Franzmann, M Jahnel, A Pozniakovsky, J Mahamid, AS Holehouse, ...
Science 359 (6371), 2018
Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
TS Harmon, AS Holehouse, MK Rosen, RV Pappu
elife 6, e30294, 2017
Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles
MT Wei*, S Elbaum-Garfinkle*, AS Holehouse*, CCH Chen, M Feric, ...
Nature Chemistry 9, 1118–1125, 2017
CIDER: Resources to analyze sequence-ensemble relationships of intrinsically disordered proteins
AS Holehouse, RK Das, JN Ahad, MOG Richardson, RV Pappu
Biophysical journal 112 (1), 16-21, 2017
Valence and patterning of aromatic residues determine the phase behavior of prion-like domains
EW Martin*, AS Holehouse*, I Peran*, M Farag, JJ Incicco, A Bremer, ...
Science 367 (6478), 694-699, 2020
Spontaneous driving forces give rise to protein− RNA condensates with coexisting phases and complex material properties
S Boeynaems, AS Holehouse, V Weinhardt, D Kovacs, J Van Lindt, ...
Proceedings of the National Academy of Sciences 116 (16), 7889-7898, 2019
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
J Guillén-Boixet, A Kopach, AS Holehouse, S Wittmann, M Jahnel, ...
Cell 181 (2), 346-361. e17, 2020
Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation
EW Martin*, AS Holehouse*, CR Grace, A Hughes, RV Pappu, T Mittag
Journal of the American Chemical Society 138 (47), 15323-15335, 2016
Physical principles underlying the complex biology of intracellular phase transitions
JM Choi, AS Holehouse, RV Pappu
Annual Review of Biophysics 49, 107-133, 2020
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution
J Fei, M Jadaliha, TS Harmon, ITS Li, B Hua, Q Hao, AS Holehouse, ...
Journal of cell science 130 (24), 4180-4192, 2017
Functional implications of intracellular phase transitions
AS Holehouse, RV Pappu
Biochemistry 57 (17), 2415-2423, 2018
Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation
AS Holehouse, K Garai, N Lyle, A Vitalis, RV Pappu
Journal of the American Chemical Society 137 (8), 2984-2995, 2015
Collapse Transitions of Proteins and the Interplay Among Backbone, Sidechain, and Solvent Interactions
AS Holehouse, RV Pappu
Annual review of Biophysics, 2018
Phase Separation of Intrinsically Disordered Proteins
AE Posey*, AS Holehouse*, RV Pappu
Methods in Enzymology, 2018
A high-throughput mutational scan of an intrinsically disordered acidic transcriptional activation domain
MV Staller, AS Holehouse, D Swain-Lenz, RK Das, RV Pappu, BA Cohen
Cell Systems 6 (4), 444-455. e6, 2018
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
J Cubuk, JJ Alston, JJ Incicco, S Singh, MD Stuchell-Brereton, MD Ward, ...
Nature communications 12 (1), 1-17, 2021
Nucleo-cytoplasmic partitioning of ARF proteins controls auxin responses in Arabidopsis thaliana
SK Powers, AS Holehouse, DA Korasick, KH Schreiber, NM Clark, H Jing, ...
Molecular cell 76 (1), 177-190. e5, 2019
OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes
AD Barrow, Y Palarasah, M Bugatti, AS Holehouse, DE Byers, ...
The Journal of Immunology 194 (7), 3317-3326, 2015
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