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Michael Shevlin
Michael Shevlin
Associate Principal Scientist, Catalysis Laboratory, Merck Research Laboratories, Merck & Co., Inc.
Bestätigte E-Mail-Adresse bei merck.com
Titel
Zitiert von
Zitiert von
Jahr
Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
A Buitrago Santanilla, EL Regalado, T Pereira, M Shevlin, K Bateman, ...
Science 347 (6217), 49-53, 2015
5362015
General principles and strategies for salting-out informed by the Hofmeister series
AM Hyde, SL Zultanski, JH Waldman, YL Zhong, M Shevlin, F Peng
Organic Process Research & Development 21 (9), 1355-1370, 2017
4212017
Cobalt precursors for high-throughput discovery of base metal asymmetric alkene hydrogenation catalysts
MR Friedfeld, M Shevlin, JM Hoyt, SW Krska, MT Tudge, PJ Chirik
Science 342 (6162), 1076-1080, 2013
3622013
Practical high-throughput experimentation for chemists
M Shevlin
ACS medicinal chemistry letters 8 (6), 601-607, 2017
3092017
The evolution of chemical high-throughput experimentation to address challenging problems in pharmaceutical synthesis
SW Krska, DA DiRocco, SD Dreher, M Shevlin
Accounts of chemical research 50 (12), 2976-2985, 2017
2612017
Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction
MR Friedfeld, H Zhong, RT Ruck, M Shevlin, PJ Chirik
Science 360 (6391), 888-893, 2018
2252018
Cobalt-catalyzed enantioselective hydrogenation of minimally functionalized alkenes: isotopic labeling provides insight into the origin of stereoselectivity and alkene …
MR Friedfeld, M Shevlin, GW Margulieux, LC Campeau, PJ Chirik
Journal of the American Chemical Society 138 (10), 3314-3324, 2016
1832016
Nickel-catalyzed asymmetric alkene hydrogenation of α, β-unsaturated esters: high-throughput experimentation-enabled reaction discovery, optimization, and mechanistic elucidation
M Shevlin, MR Friedfeld, H Sheng, NA Pierson, JM Hoyt, LC Campeau, ...
Journal of the American Chemical Society 138 (10), 3562-3569, 2016
1812016
Palladium‐Catalyzed Tandem Heck Reaction/C H Functionalization—Preparation of Spiro‐Indane‐Oxindoles
RT Ruck, MA Huffman, MM Kim, M Shevlin, WV Kandur, IW Davies
Angewandte Chemie 120 (25), 4789-4792, 2008
1802008
Iridium-catalyzed X− H insertions of sulfoxonium ylides
IK Mangion, IK Nwamba, M Shevlin, MA Huffman
Organic Letters 11 (16), 3566-3569, 2009
1642009
A concise synthesis of a β-lactamase inhibitor
IK Mangion, RT Ruck, N Rivera, MA Huffman, M Shevlin
Organic letters 13 (20), 5480-5483, 2011
1392011
Catalytic, asymmetric, and stereodivergent synthesis of non-symmetric β, β-diaryl-α-amino acids
C Molinaro, JP Scott, M Shevlin, C Wise, A Menard, A Gibb, EM Junker, ...
Journal of the American Chemical Society 137 (2), 999-1006, 2015
1062015
Cobalt-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids by Homolytic H2 Cleavage
H Zhong, M Shevlin, PJ Chirik
Journal of the American Chemical Society 142 (11), 5272-5281, 2020
802020
β-lactamase inhibitors
TA Blizzard, H Chen, C Gude, JD Hermes, J Imbriglio, S Kim, JY Wu, ...
US Patent 8,487,093, 2013
702013
Iron-Catalyzed Reductive Cyclization of o-Nitrostyrenes Using Phenylsilane as the Terminal Reductant
M Shevlin, X Guan, TG Driver
ACS Catalysis 7 (8), 5518-5522, 2017
602017
Synthesis and hydrogenation activity of iron dialkyl complexes with chiral bidentate phosphines
JM Hoyt, M Shevlin, GW Margulieux, SW Krska, MT Tudge, PJ Chirik
Organometallics 33 (20), 5781-5790, 2014
602014
Asymmetric synthesis of letermovir using a novel phase-transfer-catalyzed aza-Michael reaction
GR Humphrey, SM Dalby, T Andreani, B Xiang, MR Luzung, ZJ Song, ...
Organic Process Research & Development 20 (6), 1097-1103, 2016
562016
Sulfate additives generate robust and highly active palladium catalysts for the cyanation of aryl chlorides
M Shevlin
Tetrahedron Letters 51 (37), 4833-4836, 2010
482010
Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates
M Christensen, A Nolting, M Shevlin, M Weisel, PE Maligres, J Lee, ...
The Journal of Organic Chemistry 81 (3), 824-830, 2016
462016
Double-Asymmetric Hydrogenation Strategy for the Reduction of 1,1-Diaryl Olefins Applied to an Improved Synthesis of CuIPhEt, a C2-Symmetric N-Heterocyclic …
E Spahn, A Albright, M Shevlin, L Pauli, A Pfaltz, RE Gawley
The Journal of organic chemistry 78 (6), 2731-2735, 2013
352013
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