A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration P Koch, T Opitz, JA Steinbeck, J Ladewig, O Brüstle Proceedings of the National Academy of Sciences 106 (9), 3225-3230, 2009 | 602 | 2009 |
Small molecules enable highly efficient neuronal conversion of human fibroblasts J Ladewig, J Mertens, J Kesavan, J Doerr, D Poppe, F Glaue, S Herms, ... Nature methods 9 (6), 575-578, 2012 | 383 | 2012 |
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease P Koch, P Breuer, M Peitz, J Jungverdorben, J Kesavan, D Poppe, J Doerr, ... Nature 480 (7378), 543-546, 2011 | 369 | 2011 |
Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain K Oki, J Tatarishvili, J Wood, P Koch, S Wattananit, Y Mine, E Monni, ... Stem cells 30 (6), 1120-1133, 2012 | 356 | 2012 |
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons A Falk, P Koch, J Kesavan, Y Takashima, J Ladewig, M Alexander, ... PloS one 7 (1), e29597, 2012 | 347 | 2012 |
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies J Ladewig, P Koch, O Brüstle Nature reviews Molecular cell biology 14 (4), 225-236, 2013 | 299 | 2013 |
Inhibition of Notch Signaling in Human Embryonic Stem Cell–Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and … L Borghese, D Dolezalova, T Opitz, S Haupt, A Leinhaas, B Steinfarz, ... Stem cells 28 (5), 955-964, 2010 | 292 | 2010 |
An organoid-based model of cortical development identifies non-cell-autonomous defects in Wnt signaling contributing to Miller-Dieker syndrome V Iefremova, G Manikakis, O Krefft, A Jabali, K Weynans, R Wilkens, ... Cell reports 19 (1), 50-59, 2017 | 261 | 2017 |
Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery D Tornero, S Wattananit, M Grønning Madsen, P Koch, J Wood, ... Brain 136 (12), 3561-3577, 2013 | 261 | 2013 |
Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants T Li, JA Steinbeck, T Lusardi, P Koch, JQ Lan, A Wilz, M Segschneider, ... Brain 130 (5), 1276-1288, 2007 | 178 | 2007 |
Anticancer effects of niclosamide in human glioblastoma A Wieland, D Trageser, S Gogolok, R Reinartz, H Höfer, M Keller, ... Clinical Cancer Research 19 (15), 4124-4136, 2013 | 165 | 2013 |
Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing P Giesselmann, B Brändl, E Raimondeau, R Bowen, C Rohrandt, ... Nature biotechnology 37 (12), 1478-1481, 2019 | 157 | 2019 |
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair NS Corsini, I Sancho-Martinez, S Laudenklos, D Glagow, S Kumar, ... Cell stem cell 5 (2), 178-190, 2009 | 153 | 2009 |
Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase L Nolden, F Edenhofer, S Haupt, P Koch, FT Wunderlich, H Siemen, ... Nature methods 3 (6), 461-467, 2006 | 152 | 2006 |
Generation of functional human serotonergic neurons from fibroblasts KC Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, ... Molecular psychiatry 21 (1), 49-61, 2016 | 142 | 2016 |
Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling P Koch, Z Kokaia, O Lindvall, O Brüstle The Lancet Neurology 8 (9), 819-829, 2009 | 137 | 2009 |
Presenilin-1 L166P mutant human pluripotent stem cell–derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation P Koch, IY Tamboli, J Mertens, P Wunderlich, J Ladewig, K Stüber, ... The American journal of pathology 180 (6), 2404-2416, 2012 | 136 | 2012 |
Specific inhibition of β-secretase processing of the Alzheimer disease amyloid precursor protein SB Halima, S Mishra, KMP Raja, M Willem, A Baici, K Simons, O Brüstle, ... Cell reports 14 (9), 2127-2141, 2016 | 133 | 2016 |
Autonomous rhythmic activity in glioma networks drives brain tumour growth D Hausmann, DC Hoffmann, V Venkataramani, E Jung, S Horschitz, ... Nature 613 (7942), 179-186, 2023 | 111 | 2023 |
Nucleofection of human embryonic stem cells H Siemen, M Nix, E Endl, P Koch, J Itskovitz-Eldor, O Brüstle Stem Cells and Development 14 (4), 378-383, 2005 | 110 | 2005 |