|Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice|
Q Chen, M Khoury, J Chen
Proceedings of the National Academy of Sciences 106 (51), 21783-21788, 2009
|Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations|
KM Loh, LT Ang, J Zhang, V Kumar, J Ang, JQ Auyeong, KL Lee, ...
Cell stem cell 14 (2), 237-252, 2014
|Mapping the human DC lineage through the integration of high-dimensional techniques|
P See, CA Dutertre, J Chen, P Günther, N McGovern, SE Irac, M Gunawan, ...
Science 356 (6342), 2017
|Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma|
M Garnelo, A Tan, Z Her, J Yeong, CJ Lim, J Chen, KH Lim, A Weber, ...
Gut 66 (2), 342-351, 2017
|GM-CSF and IL-4 stimulate antibody responses in humanized mice by promoting T, B, and dendritic cell maturation|
Q Chen, F He, J Kwang, JKY Chan, J Chen
The Journal of Immunology 189 (11), 5223-5229, 2012
|Opposing activities of the R as and H ippo pathways converge on regulation of YAP protein turnover|
X Hong, HT Nguyen, Q Chen, R Zhang, Z Hagman, PM Voorhoeve, ...
The EMBO journal 33 (21), 2447-2457, 2014
|Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells|
Q Chen, A Amaladoss, W Ye, M Liu, S Dummler, F Kong, LH Wong, ...
Proceedings of the National Academy of Sciences 111 (4), 1479-1484, 2014
|Engineering humanized mice for improved hematopoietic reconstitution|
AC Drake, Q Chen, J Chen
Cellular & molecular immunology 9 (3), 215-224, 2012
|Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential|
M Khoury, A Drake, Q Chen, D Dong, I Leskov, MF Fragoso, Y Li, ...
Stem cells and development 20 (8), 1371-1381, 2011
|Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice|
A Sridharan, Q Chen, KF Tang, EE Ooi, ML Hibberd, J Chen
Journal of virology 87 (21), 11648-11658, 2013
|CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses|
SZ Chong, M Evrard, S Devi, J Chen, JY Lim, P See, Y Zhang, JM Adrover, ...
Journal of Experimental Medicine 213 (11), 2293-2314, 2016
|A roadmap for human liver differentiation from pluripotent stem cells|
LT Ang, AKY Tan, MI Autio, SH Goh, SH Choo, KL Lee, J Tan, B Pan, ...
Cell reports 22 (8), 2190-2205, 2018
|Human fetal hepatic progenitor cells are distinct from, but closely related to, hematopoietic stem/progenitor cells|
Q Chen, M Khoury, G Limmon, M Choolani, JKY Chan, J Chen
Stem cells 31 (6), 1160-1169, 2013
|Development of a new patient-derived xenograft humanised mouse model to study human-specific tumour microenvironment and immunotherapy|
Y Zhao, TWH Shuen, TB Toh, XY Chan, M Liu, SY Tan, Y Fan, H Yang, ...
Gut 67 (10), 1845-1854, 2018
|Addressing drug resistance in cancer with macromolecular chemotherapeutic agents|
NH Park, W Cheng, F Lai, C Yang, P Florez de Sessions, B Periaswamy, ...
Journal of the American Chemical Society 140 (12), 4244-4252, 2018
|Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice|
Y Zhao, M Liu, XY Chan, SY Tan, S Subramaniam, Y Fan, E Loh, ...
Blood, The Journal of the American Society of Hematology 130 (18), 1995-2005, 2017
|Humanized mice as unique tools for human-specific studies|
KSM Yong, Z Her, Q Chen
Archivum immunologiae et therapiae experimentalis 66 (4), 245-266, 2018
|Microstructured dextran hydrogels for burst-free sustained release of PEGylated protein drugs|
KH Bae, F Lee, K Xu, CT Keng, SY Tan, YJ Tan, Q Chen, M Kurisawa
Biomaterials 63, 146-157, 2015
|Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice|
Y Li, Q Chen, D Zheng, L Yin, YH Chionh, LH Wong, SQ Tan, TC Tan, ...
The Journal of Immunology 191 (6), 3192-3199, 2013
|Dengue virus-infected dendritic cells, but not monocytes, activate natural killer cells through a contact-dependent mechanism involving adhesion molecules|
VV Costa, W Ye, Q Chen, MM Teixeira, P Preiser, EE Ooi, J Chen
MBio 8 (4), 2017