| Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization MA Sanders, G Brahemi, P Nangia-Makker, V Balan, M Morelli, ... Molecular cancer therapeutics 12 (4), 373-383, 2013 | 69 | 2013 |
| RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance RR Somasagara, SM Spencer, K Tripathi, DW Clark, C Mani, ... Oncogene 36 (48), 6680-6690, 2017 | 65 | 2017 |
| Synthesis and in vitro anticancer evaluation of some 4, 6-diamino-1, 3, 5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors H Kothayer, SM Spencer, K Tripathi, AD Westwell, K Palle Bioorganic & medicinal chemistry letters 26 (8), 2030-2034, 2016 | 57 | 2016 |
| Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation … B Haynes, Y Zhang, F Liu, J Li, S Petit, H Kothayer, X Bao, AD Westwell, ... Nanomedicine: Nanotechnology, Biology and Medicine 12 (3), 745-757, 2016 | 47 | 2016 |
| Synthesis of New 2,3‐Dihydroquinazolin‐4(1H)‐one Derivatives for Analgesic and Anti‐inflammatory Evaluation OI El‐Sabbagh, SM Ibrahim, MM Baraka, H Kothayer Archiv der Pharmazie: An International Journal Pharmaceutical and Medicinal …, 2010 | 43 | 2010 |
| Synthesis, anticonvulsant activity, and SAR study of novel 4‐quinazolinone derivatives NA Noureldin, H Kothayer, ESM Lashine, MM Baraka, W El‐Eraky, ... Archiv der Pharmazie 350 (2), 1600332, 2017 | 32 | 2017 |
| Novel 1, 2, 4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition AM Ghanim, S Rezq, TS Ibrahim, DG Romero, H Kothayer European journal of medicinal chemistry 219, 113457, 2021 | 30 | 2021 |
| Design, synthesis and in vitro anticancer evaluation of 4, 6-diamino-1, 3, 5-triazine-2-carbohydrazides and-carboxamides H Kothayer, AA Elshanawani, MEA Kull, OI El-Sabbagh, MPV Shekhar, ... Bioorganic & medicinal chemistry letters 23 (24), 6886-6889, 2013 | 29 | 2013 |
| Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity SM Ibrahim, MM Baraka, OI El-Sabbagh, H Kothayer Medicinal Chemistry Research 22, 1488-1496, 2013 | 29 | 2013 |
| Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and … A Sakr, S Rezq, SM Ibrahim, E Soliman, MM Baraka, DG Romero, ... Journal of Enzyme Inhibition and Medicinal Chemistry 36 (1), 1810-1828, 2021 | 26 | 2021 |
| 1, 4-dihydroquinazolin-3 (2h)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, cox-1/2 inhibitory … A Sakr, H Kothayer, SM Ibrahim, MM Baraka, S Rezq Bioorganic Chemistry 84, 76-86, 2019 | 23 | 2019 |
| Design, synthesis and biological evaluation of novel quinazoline-2, 4-diones conjugated with different amino acids as potential chitin synthase inhibitors NA Noureldin, H Kothayer, ESM Lashine, MM Baraka, Y Huang, B Li, Q Ji European Journal of Medicinal Chemistry 152, 560-569, 2018 | 20 | 2018 |
| Synthesis, in vivo and in silico evaluation of novel 2, 3‐dihydroquinazolin‐4 (1H)‐one derivatives as potential anticonvulsant agents H Kothayer, SM Ibrahim, MK Soltan, S Rezq, SS Mahmoud Drug Development Research 80 (3), 343-352, 2019 | 18 | 2019 |
| Optimised synthesis of diamino-triazinylmethyl benzoates as inhibitors of Rad6B ubiquitin conjugating enzyme H Kothayer, M Morelli, G Brahemi, AA Elshanawani, MEA Kull, ... Tetrahedron letters 55 (51), 7015-7018, 2014 | 11 | 2014 |
| Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti … H Kothayer, S Rezq, AS Abdelkhalek, DG Romero, SS Elbaramawi Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2199166, 2023 | 8 | 2023 |
| Quinazoline‐tethered hydrazone: a versatile scaffold toward dual anti‐TB and EGFR inhibition activities in NSCLC AM Emam, A Dahal, SS Singh, RD Tosso, SM Ibrahim, M El‐Sadek, ... Archiv der Pharmazie 354 (12), 2100281, 2021 | 6 | 2021 |
| Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation NA Noureldin, J Richards, H Kothayer, MM Baraka, SM Eladl, M Wootton, ... RSC advances 12 (4), 2511-2524, 2022 | 5 | 2022 |
| Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent … S Elsayed, AS Abdelkhalek, S Rezq, MEA Kull, DG Romero, H Kothayer European Journal of Medicinal Chemistry 260, 115724, 2023 | 4 | 2023 |
| Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines AS Abdelkhalek, H Kothayer, S Rezq, KY Orabi, DG Romero, ... European Journal of Medicinal Chemistry 256, 115443, 2023 | 4 | 2023 |
| Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation … B Haynes, Y Zhang, F Liu, J Li, S Petit, H Kothayer, X Bao, AD Westwell, ... NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 18, 426-426, 2019 | 2 | 2019 |
