| Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis EE Zhang, Y Liu, R Dentin, PY Pongsawakul, AC Liu, T Hirota, ... Nature medicine 16 (10), 1152-1156, 2010 | 622 | 2010 |
| A genome-wide RNAi screen for modifiers of the circadian clock in human cells EE Zhang, AC Liu, T Hirota, LJ Miraglia, G Welch, PY Pongsawakul, X Liu, ... Cell 139 (1), 199-210, 2009 | 490 | 2009 |
| Identification of small molecule activators of cryptochrome T Hirota, JW Lee, PC St. John, M Sawa, K Iwaisako, T Noguchi, ... Science 337 (6098), 1094-1097, 2012 | 484 | 2012 |
| Glucose Down-regulates Per1 and Per2mRNA Levels and Induces Circadian Gene Expression in Cultured Rat-1 Fibroblasts* 210 T Hirota, T Okano, K Kokame, H Shirotani-Ikejima, T Miyata, Y Fukada Journal of Biological Chemistry 277 (46), 44244-44251, 2002 | 381 | 2002 |
| Resetting mechanism of central and peripheral circadian clocks in mammals T Hirota, Y Fukada Zoological science 21 (4), 359-368, 2004 | 339 | 2004 |
| A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β T Hirota, WG Lewis, AC Liu, JW Lee, PG Schultz, SA Kay Proceedings of the National Academy of Sciences 105 (52), 20746-20751, 2008 | 315 | 2008 |
| High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase T Hirota, JW Lee, WG Lewis, EE Zhang, G Breton, X Liu, M Garcia, ... PLoS biology 8 (12), e1000559, 2010 | 272 | 2010 |
| Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3β Y Harada, M Sakai, N Kurabayashi, T Hirota, Y Fukada Journal of Biological Chemistry 280 (36), 31714-31721, 2005 | 257 | 2005 |
| Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies M Hatori, C Gronfier, RN Van Gelder, PS Bernstein, J Carreras, S Panda, ... npj Aging and Mechanisms of Disease 3 (1), 9, 2017 | 200 | 2017 |
| DYRK1A and glycogen synthase kinase 3β, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping N Kurabayashi, T Hirota, M Sakai, K Sanada, Y Fukada Molecular and cellular biology, 2010 | 177 | 2010 |
| Circadian amplitude regulation via FBXW7-targeted REV-ERBα degradation X Zhao, T Hirota, X Han, H Cho, LW Chong, K Lamia, S Liu, AR Atkins, ... Cell 165 (7), 1644-1657, 2016 | 159 | 2016 |
| Activation of TGF-β/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts N Kon, T Hirota, T Kawamoto, Y Kato, T Tsubota, Y Fukada Nature cell biology 10 (12), 1463-1469, 2008 | 151 | 2008 |
| Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation T Okano, K Yamamoto, K Okano, T Hirota, T Kasahara, M Sasaki, ... Genes to Cells 6 (9), 825-836, 2001 | 116 | 2001 |
| Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth T Oshima, Y Niwa, K Kuwata, A Srivastava, T Hyoda, Y Tsuchiya, ... Science advances 5 (1), eaau9060, 2019 | 106 | 2019 |
| Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock TN Uehara, Y Mizutani, K Kuwata, T Hirota, A Sato, J Mizoi, S Takao, ... Proceedings of the National Academy of Sciences 116 (23), 11528-11536, 2019 | 77 | 2019 |
| Nuclear receptor HNF4A transrepresses CLOCK: BMAL1 and modulates tissue-specific circadian networks M Qu, T Duffy, T Hirota, SA Kay Proceedings of the National Academy of Sciences 115 (52), E12305-E12312, 2018 | 76 | 2018 |
| C H Activation Generates Period‐Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock T Oshima, I Yamanaka, A Kumar, J Yamaguchi, T Nishiwaki‐Ohkawa, ... Angewandte Chemie International Edition 54 (24), 7193-7197, 2015 | 73 | 2015 |
| Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways M Hatori, T Hirota, M Iitsuka, N Kurabayashi, S Haraguchi, K Kokame, ... Proceedings of the National Academy of Sciences 108 (12), 4864-4869, 2011 | 72 | 2011 |
| Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock PC St. John, T Hirota, SA Kay, FJ Doyle III Proceedings of the National Academy of Sciences 111 (5), 2040-2045, 2014 | 71 | 2014 |
| A small molecule modulates circadian rhythms through phosphorylation of the period protein JW Lee, T Hirota, EC Peters, M Garcia, R Gonzalez, CY Cho, X Wu, ... Angewandte Chemie (International ed. in English) 50 (45), 10608, 2011 | 69 | 2011 |
