Jonathan M. Shillingford, Ph.D.
Jonathan M. Shillingford, Ph.D.
Research Assistant Professor
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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease
JM Shillingford, NS Murcia, CH Larson, SH Low, R Hedgepeth, N Brown, ...
Proceedings of the National Academy of Sciences 103 (14), 5466-5471, 2006
Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
K Miyoshi, JM Shillingford, GH Smith, SL Grimm, KU Wagner, T Oka, ...
The Journal of cell biology 155 (4), 531-542, 2001
Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
JM Shillingford, KB Piontek, GG Germino, T Weimbs
Journal of the American Society of Nephrology 21 (3), 489-497, 2010
Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5
W Long, KU Wagner, KCK Lloyd, N Binart, JM Shillingford, ...
Development 130 (21), 5257-5268, 2003
Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function
Y Sun, K Boyd, W Xu, J Ma, CW Jackson, A Fu, JM Shillingford, ...
Molecular and cellular biology 26 (15), 5809-5826, 2006
Activation of β-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
B Bierie, M Nozawa, JP Renou, JM Shillingford, F Morgan, T Oka, ...
Oncogene 22 (25), 3875-3887, 2003
Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias
K Miyoshi, JM Shillingford, F Le Provost, F Gounari, R Bronson, ...
Proceedings of the National Academy of Sciences 99 (1), 219-224, 2002
Polycystin-1 regulates STAT activity by a dual mechanism
JJ Talbot, JM Shillingford, S Vasanth, N Doerr, S Mukherjee, MT Kinter, ...
Proceedings of the National Academy of Sciences 108 (19), 7985-7990, 2011
Folate-conjugated rapamycin slows progression of polycystic kidney disease
JM Shillingford, CP Leamon, IR Vlahov, T Weimbs
Journal of the American Society of Nephrology 23 (10), 1674-1681, 2012
Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium
JM Shillingford, K Miyoshi, GW Robinson, SL Grimm, JM Rosen, ...
Molecular endocrinology 16 (3), 563-570, 2002
Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation
KD Walton, KU Wagner, EB Rucker III, JM Shillingford, K Miyoshi, ...
Mechanisms of development 109 (2), 281-293, 2001
Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease
EE Olsan, S Mukherjee, B Wulkersdorfer, JM Shillingford, AJ Giovannone, ...
Proceedings of the National Academy of Sciences 108 (44), 18067-18072, 2011
Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues
S Cases, P Zhou, JM Shillingford, BS Wiseman, JD Fish, CS Angle, ...
Development 131 (13), 3047-3055, 2004
Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions
JM Shillingford, K Miyoshi, GW Robinson, B Bierie, Y Cao, M Karin, ...
Journal of Histochemistry & Cytochemistry 51 (5), 555-565, 2003
Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis
JM Shillingford, K Miyoshi, M Flagella, GE Shull, L Hennighausen
Molecular endocrinology 16 (6), 1309-1321, 2002
Experimental mouse genetics–answering fundamental questions about mammary gland biology
JM Shillingford, L Hennighausen
Trends in Endocrinology & Metabolism 12 (9), 402-408, 2001
Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease
T Weimbs, JM Shillingford, J Torres, SL Kruger, BC Bourgeois
Clinical kidney journal 11 (suppl_1), i27-i38, 2018
Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease
KR Kipp, SL Kruger, MF Schimmel, N Parker, JM Shillingford, CP Leamon, ...
American Journal of Physiology-Renal Physiology 315 (2), F395-F405, 2018
Phosphate transport via Na+‐Pi cotransport and anion exchange in lactating rat mammary tissue
JM Shillingford, DT Calvert, RB Beechey, DB Shennan
Experimental Physiology: Translation and Integration 81 (2), 273-284, 1996
Image segmentation, registration and visualization of serial MR images for therapeutic assessment of polycystic kidney disease in transgenic mice
B Fei, C Flask, H Wang, A Pi, DL Wilson, J Shillingford, N Murcia, ...
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 467-469, 2006
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