Tim Wang
Tim Wang
Allen Institute
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Cited by
Cited by
Genetic screens in human cells using the CRISPR-Cas9 system
T Wang, JJ Wei, DM Sabatini, ES Lander
Science 343 (6166), 80-84, 2014
Identification and characterization of essential genes in the human genome
T Wang, K Birsoy, NW Hughes, KM Krupczak, Y Post, JJ Wei, ES Lander, ...
Science 350 (6264), 1096-1101, 2015
Cellpose: a generalist algorithm for cellular segmentation
C Stringer, T Wang, M Michaelos, M Pachitariu
Nature methods 18 (1), 100-106, 2021
A unifying model for mTORC1-mediated regulation of mRNA translation
CC Thoreen, L Chantranupong, HR Keys, T Wang, NS Gray, DM Sabatini
Nature 485 (7396), 109-113, 2012
An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
K Birsoy, T Wang, WW Chen, E Freinkman, M Abu-Remaileh, DM Sabatini
Cell 162 (3), 540-551, 2015
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites
S Schwartz, MR Mumbach, M Jovanovic, T Wang, K Maciag, GG Bushkin, ...
Cell reports 8 (1), 284-296, 2014
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ...
Science 347 (6218), 188-194, 2015
The CASTOR proteins are arginine sensors for the mTORC1 pathway
L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ...
Cell 165 (1), 153-164, 2016
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
K Birsoy, R Possemato, FK Lorbeer, EC Bayraktar, P Thiru, B Yucel, ...
Nature 508 (7494), 108-112, 2014
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes
SM Sidik, D Huet, SM Ganesan, MH Huynh, T Wang, AS Nasamu, P Thiru, ...
Cell 166 (6), 1423-1435. e12, 2016
Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras
T Wang, H Yu, NW Hughes, B Liu, A Kendirli, K Klein, WW Chen, ...
Cell 168 (5), 890-903. e15, 2017
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
ZY Tsun, L Bar-Peled, L Chantranupong, R Zoncu, T Wang, C Kim, ...
Molecular cell 52 (4), 495-505, 2013
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
RA Saxton, KE Knockenhauer, RL Wolfson, L Chantranupong, ME Pacold, ...
Science 351 (6268), 53-58, 2016
Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism
WW Chen, E Freinkman, T Wang, K Birsoy, DM Sabatini
Cell 166 (5), 1324-1337. e11, 2016
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
RJ Park, T Wang, D Koundakjian, JF Hultquist, P Lamothe-Molina, ...
Nature genetics 49 (2), 193-203, 2017
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
K Birsoy, T Wang, R Possemato, OH Yilmaz, CE Koch, WW Chen, ...
Nature genetics 45 (1), 104-108, 2013
Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma
K Revill, T Wang, A Lachenmayer, K Kojima, A Harrington, J Li, Y Hoshida, ...
Gastroenterology 145 (6), 1424-1435. e25, 2013
Systematic identification of signaling pathways with potential to confer anticancer drug resistance
CA Martz, KA Ottina, KR Singleton, JS Jasper, SE Wardell, ...
Science signaling 7 (357), ra121-ra121, 2014
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism
N Kory, GA Wyant, G Prakash, J uit de Bos, F Bottanelli, ME Pacold, ...
Science 362 (6416), eaat9528, 2018
A CRISPR screen identifies a pathway required for paraquat-induced cell death
CR Reczek, K Birsoy, H Kong, I Martínez-Reyes, T Wang, P Gao, ...
Nature chemical biology 13 (12), 1274-1279, 2017
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