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Gerald Krystal
Gerald Krystal
Distinguished Scientist, B.C. Cancer, Professor of Pathology & Laboratory Medicine, University of British Columbia
Bestätigte E-Mail-Adresse bei bccrc.ca - Startseite
Titel
Zitiert von
Zitiert von
Jahr
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3, 4, 5-triphosphate 5-phosphatase.
JE Damen, L Liu, P Rosten, RK Humphries, AB Jefferson, PW Majerus, ...
Proceedings of the National Academy of Sciences 93 (4), 1689-1693, 1996
8191996
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
CD Helgason, JE Damen, P Rosten, R Grewal, P Sorensen, SM Chappel, ...
Genes & development 12 (11), 1610-1620, 1998
7281998
Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
J Kalesnikoff, M Huber, V Lam, JE Damen, J Zhang, RP Siraganian, ...
Immunity 14 (6), 801-811, 2001
4932001
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis
T Yi, ALF Mui, G Krystal, JN Ihle
Molecular and Cellular Biology 13 (12), 7577-7586, 1993
4711993
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation
M Huber, CD Helgason, JE Damen, L Liu, RK Humphries, G Krystal
Proceedings of the National Academy of Sciences 95 (19), 11330-11335, 1998
3851998
LPS-induced upregulation of SHIP is essential for endotoxin tolerance
LM Sly, MJ Rauh, J Kalesnikoff, CH Song, G Krystal
Immunity 21 (2), 227-239, 2004
3792004
Multiple pathways involved in the biosynthesis of anandamide
J Liu, L Wang, J Harvey-White, BX Huang, HY Kim, S Luquet, RD Palmiter, ...
Neuropharmacology 54 (1), 1-7, 2008
3632008
SHIP represses the generation of alternatively activated macrophages
MJ Rauh, V Ho, C Pereira, A Sham, LM Sly, V Lam, L Huxham, ...
Immunity 23 (4), 361-374, 2005
3372005
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation.
JE Damen, H Wakao, A Miyajima, J Krosl, RK Humphries, RL Cutler, ...
The EMBO journal 14 (22), 5557-5568, 1995
3321995
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
S Takeshita, N Namba, JJ Zhao, Y Jiang, HK Genant, MJ Silva, MD Brodt, ...
Nature medicine 8 (9), 943-949, 2002
2932002
Inhibition of antigen‐induced T cell response and antibody‐induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP‐1 and SHP‐2 protein‐tyrosine phosphatases
E Le Dréan, F Vély, L Olcese, A Cambiaggi, S Guia, G Krystal, N Gervois, ...
European journal of immunology 28 (1), 264-276, 1998
2931998
Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.
RL Cutler, L Liu, JE Damen, G Krystal
Journal of Biological Chemistry 268 (29), 21463-21465, 1993
2811993
Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP
H Valderrama-Carvajal, E Cocolakis, A Lacerte, EH Lee, G Krystal, S Ali, ...
Nature cell biology 4 (12), 963-969, 2002
2592002
Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
JE Damen, L Liu, RL Cutler, G Krystal
2551993
A simple microassay for erythropoietin based on 3H-thymidine incorporation into spleen cells from phenylhydrazine treated mice.
G Krystal
Experimental hematology 11 (7), 649-660, 1983
2541983
Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3, 4) P2 is required for PKB phosphorylation at …
MP Scheid, M Huber, JE Damen, M Hughes, V Kang, P Neilsen, ...
Journal of Biological Chemistry 277 (11), 9027-9035, 2002
2262002
Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc
L Liu, JE Damen, RL Cutler, G Krystal
Molecular and cellular biology 14 (10), 6926-6935, 1994
2231994
Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.
GW Chacko, S Tridandapani, JE Damen, L Liu, G Krystal, KM Coggeshall
Journal of immunology (Baltimore, Md.: 1950) 157 (6), 2234-2238, 1996
2151996
A dual role for Src homology 2 domain–containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of B lymphocytes in SHIP−/− mice
CD Helgason, CP Kalberer, JE Damen, SM Chappel, N Pineault, ...
The Journal of experimental medicine 191 (5), 781-794, 2000
2082000
Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3 …
JE Damen, RL Cutler, H Jiao, T Yi, G Krystal
Journal of Biological Chemistry 270 (40), 23402-23408, 1995
2081995
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