| Glycosyltransferases: structures, functions, and mechanisms LL Lairson, B Henrissat, GJ Davies, SG Withers Annu. Rev. Biochem. 77, 521-555, 2008 | 2148 | 2008 |
| A regenerative approach to the treatment of multiple sclerosis VA Deshmukh, V Tardif, CA Lyssiotis, CC Green, B Kerman, HJ Kim, ... Nature 502 (7471), 327-332, 2013 | 515 | 2013 |
| Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, ... Proceedings of the National Academy of Sciences 106 (22), 8912-8917, 2009 | 493 | 2009 |
| Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers E Mullarky, NC Lucki, R Beheshti Zavareh, JL Anglin, AP Gomes, ... Proceedings of the National Academy of Sciences 113 (7), 1778-1783, 2016 | 292 | 2016 |
| Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic EN Chin, C Yu, VF Vartabedian, Y Jia, M Kumar, AM Gamo, W Vernier, ... Science 369 (6506), 993-999, 2020 | 289 | 2020 |
| High-throughput screening methodology for the directed evolution of glycosyltransferases A Aharoni, K Thieme, CPC Chiu, S Buchini, LL Lairson, H Chen, ... Nature Methods 3 (8), 609-614, 2006 | 274 | 2006 |
| Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog CPC Chiu, AG Watts, LL Lairson, M Gilbert, D Lim, WW Wakarchuk, ... Nature structural & molecular biology 11 (2), 163-170, 2004 | 272 | 2004 |
| A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling MJ Bollong, G Lee, JS Coukos, H Yun, C Zambaldo, JW Chang, EN Chin, ... Nature 562 (7728), 600-604, 2018 | 229 | 2018 |
| An activity-guided map of electrophile-cysteine interactions in primary human T cells EV Vinogradova, X Zhang, D Remillard, DC Lazar, RM Suciu, Y Wang, ... Cell 182 (4), 1009-1026. e29, 2020 | 215 | 2020 |
| Systems biology guided by XCMS Online metabolomics T Huan, EM Forsberg, D Rinehart, CH Johnson, J Ivanisevic, HP Benton, ... Nature methods 14 (5), 461-462, 2017 | 187 | 2017 |
| An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation H Wurdak, S Zhu, A Romero, M Lorger, J Watson, C Chiang, J Zhang, ... Cell stem cell 6 (1), 37-47, 2010 | 184 | 2010 |
| Chemical control of stem cell fate and developmental potential CA Lyssiotis, LL Lairson, AE Boitano, H Wurdak, S Zhu, PG Schultz Angewandte Chemie International Edition 50 (1), 200-242, 2011 | 150 | 2011 |
| A small molecule accelerates neuronal differentiation in the adult rat H Wurdak, S Zhu, KH Min, L Aimone, LL Lairson, J Watson, G Chopiuk, ... Proceedings of the National Academy of Sciences 107 (38), 16542-16547, 2010 | 133 | 2010 |
| Intermediate trapping on a mutant retaining α-galactosyltransferase identifies an unexpected aspartate residue LL Lairson, CPC Chiu, HD Ly, S He, WW Wakarchuk, NCJ Strynadka, ... Journal of Biological Chemistry 279 (27), 28339-28344, 2004 | 126 | 2004 |
| Mechanistic analogies amongst carbohydrate modifying enzymes LL Lairson, SG Withers Chemical communications, 2243-2248, 2004 | 120 | 2004 |
| Structural Analysis of the α-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms, CPC Chiu, LL Lairson, M Gilbert, WW Wakarchuk, SG Withers, ... Biochemistry 46 (24), 7196-7204, 2007 | 109 | 2007 |
| A small molecule inhibits deregulated NRF2 transcriptional activity in cancer MJ Bollong, H Yun, L Sherwood, AK Woods, LL Lairson, PG Schultz ACS chemical biology 10 (10), 2193-2198, 2015 | 94 | 2015 |
| Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation BA Beyer, M Fang, B Sadrian, JR Montenegro-Burke, WC Plaisted, ... Nature chemical biology 14 (1), 22-28, 2018 | 93 | 2018 |
| Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis LL Lairson, AG Watts, WW Wakarchuk, SG Withers Nature Chemical Biology 2 (12), 724-728, 2006 | 82 | 2006 |
| A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers MJ Bollong, M Pietilä, AD Pearson, TR Sarkar, I Ahmad, R Soundararajan, ... Proceedings of the National Academy of Sciences 114 (46), E9903-E9912, 2017 | 75 | 2017 |
