| Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein MH Orzalli, NA DeLuca, DM Knipe Proceedings of the National Academy of Sciences 109 (44), E3008-E3017, 2012 | 471 | 2012 |
| A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction KS Bonham, MH Orzalli, K Hayashi, AI Wolf, C Glanemann, W Weninger, ... Cell 156 (4), 705-716, 2014 | 276 | 2014 |
| cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection MH Orzalli, NM Broekema, BA Diner, DC Hancks, NC Elde, IM Cristea, ... Proceedings of the National Academy of Sciences 112 (14), E1773-E1781, 2015 | 267 | 2015 |
| Apoptosis and necroptosis as host defense strategies to prevent viral infection MH Orzalli, JC Kagan Trends in cell biology 27 (11), 800-809, 2017 | 223 | 2017 |
| Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA MH Orzalli, SE Conwell, C Berrios, JA DeCaprio, DM Knipe Proceedings of the National Academy of Sciences 110 (47), E4492-E4501, 2013 | 183 | 2013 |
| Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation CC de Oliveira Mann, MH Orzalli, DS King, JC Kagan, ASY Lee, ... Cell reports 27 (4), 1165-1175. e5, 2019 | 159 | 2019 |
| Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach MN Lee, M Roy, SE Ong, P Mertins, AC Villani, W Li, F Dotiwala, J Sen, ... Nature immunology 14 (2), 179-185, 2013 | 120 | 2013 |
| Cellular sensing of viral DNA and viral evasion mechanisms MH Orzalli, DM Knipe Annual review of microbiology 68, 477-492, 2014 | 113 | 2014 |
| An antiviral branch of the IL-1 signaling pathway restricts immune-evasive virus replication MH Orzalli, A Smith, KA Jurado, A Iwasaki, JA Garlick, JC Kagan Molecular cell 71 (5), 825-840. e6, 2018 | 91 | 2018 |
| Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells MH Orzalli, A Prochera, L Payne, A Smith, JA Garlick, JC Kagan Immunity 54 (7), 1447-1462. e5, 2021 | 79 | 2021 |
| Innate immune mechanisms and herpes simplex virus infection and disease EA Kurt-Jones, MH Orzalli, DM Knipe Cell Biology of Herpes Viruses, 49-75, 2017 | 75 | 2017 |
| Mechanisms of host IFI16, PML, and Daxx protein restriction of herpes simplex virus 1 replication PE Merkl, MH Orzalli, DM Knipe Journal of virology 92 (10), 10.1128/jvi. 00057-18, 2018 | 69 | 2018 |
| Relative contributions of herpes simplex virus 1 ICP0 and vhs to loss of cellular IFI16 vary in different human cell types MH Orzalli, NM Broekema, DM Knipe Journal of virology 90 (18), 8351-8359, 2016 | 67 | 2016 |
| A Premature Termination Codon Mutation at the C Terminus of Foamy Virus Gag Downregulates the Levels of Spliced pol mRNA EG Lee, D Kuppers, M Horn, J Roy, C May, ML Linial Journal of virology 82 (4), 1656-1664, 2008 | 13 | 2008 |
| Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity R Bharadwaj, CF Lusi, S Mashayekh, A Nagar, M Subbarao, GI Kane, ... Immunity 56 (5), 998-1012. e8, 2023 | 8 | 2023 |
| Effector-triggered immunity in mammalian antiviral defense MH Orzalli, P Parameswaran Trends in Immunology 43 (12), 1006-1017, 2022 | 7 | 2022 |
| Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces K Maeda, NC Zachos, MH Orzalli, SS Schmieder, D Chang, KB Gwilt, ... Cell host & microbe 30 (2), 216-231. e5, 2022 | 6 | 2022 |
| A one-protein signaling pathway in the innate immune system MH Orzalli, JC Kagan Science immunology 1 (2), eaah6184-eaah6184, 2016 | 3 | 2016 |
| Herpes simplex virus infected cell protein 8 is required for viral inhibition of the cGAS pathway N Broekema, ME Mertens, M Angelova, MH Orzalli, HS Oh, DM Knipe Virology 585, 34-41, 2023 | 1 | 2023 |
| An orphan no more: Nur77 senses cytosolic LPS MH Orzalli Immunity 56 (4), 742-744, 2023 | 1 | 2023 |
