Megan Orzalli
Megan Orzalli
Assistant Professor
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Cited by
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
MH Orzalli, NA DeLuca, DM Knipe
Proceedings of the National Academy of Sciences 109 (44), E3008-E3017, 2012
A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction
KS Bonham, MH Orzalli, K Hayashi, AI Wolf, C Glanemann, W Weninger, ...
Cell 156 (4), 705-716, 2014
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
MH Orzalli, NM Broekema, BA Diner, DC Hancks, NC Elde, IM Cristea, ...
Proceedings of the National Academy of Sciences 112 (14), E1773-E1781, 2015
Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA
MH Orzalli, SE Conwell, C Berrios, JA DeCaprio, DM Knipe
Proceedings of the National Academy of Sciences 110 (47), E4492-E4501, 2013
Apoptosis and necroptosis as host defense strategies to prevent viral infection
MH Orzalli, JC Kagan
Trends in cell biology 27 (11), 800-809, 2017
Cellular sensing of viral DNA and viral evasion mechanisms
MH Orzalli, DM Knipe
Annual review of microbiology 68, 477-492, 2014
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
MN Lee, M Roy, SE Ong, P Mertins, AC Villani, W Li, F Dotiwala, J Sen, ...
Nature immunology 14 (2), 179-185, 2013
Relative contributions of herpes simplex virus 1 ICP0 and vhs to loss of cellular IFI16 vary in different human cell types
MH Orzalli, NM Broekema, DM Knipe
Journal of virology 90 (18), 8351-8359, 2016
Mechanisms of host IFI16, PML, and Daxx protein restriction of herpes simplex virus 1 replication
PE Merkl, MH Orzalli, DM Knipe
Journal of virology 92 (10), e00057-18, 2018
Modular architecture of the STING C-terminal tail allows interferon and NF-κB signaling adaptation
CC de Oliveira Mann, MH Orzalli, DS King, JC Kagan, ASY Lee, ...
Cell reports 27 (4), 1165-1175. e5, 2019
Innate immune mechanisms and herpes simplex virus infection and disease
EA Kurt-Jones, MH Orzalli, DM Knipe
Cell Biology of Herpes Viruses, 49-75, 2017
An antiviral branch of the IL-1 signaling pathway restricts immune-evasive virus replication
MH Orzalli, A Smith, KA Jurado, A Iwasaki, JA Garlick, JC Kagan
Molecular cell 71 (5), 825-840. e6, 2018
Apparatus for producing a nonwoven web
HG Geus, HJ Hofemeister, F Rösner, D Frey, K Sievers, U Schomer
US Patent 6,908,292, 2005
A Premature Termination Codon Mutation at the C Terminus of Foamy Virus Gag Downregulates the Levels of Spliced pol mRNA
EG Lee, D Kuppers, M Horn, J Roy, C May, ML Linial
Journal of virology 82 (4), 1656-1664, 2008
A one-protein signaling pathway in the innate immune system
MH Orzalli, JC Kagan
Science immunology 1 (2), eaah6184, 2016
Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells
MH Orzalli, A Prochera, L Payne, A Smith, JA Garlick, JC Kagan
Immunity, 2021
Human Skin Explants Recapitulate Key Features of HSV-1 Infections
MH Orzalli
Journal of Investigative Dermatology 139 (3), 519-521, 2019
Inhibition of nuclear DNA sensing by herpes simplex virus 1
MH Orzalli
Harvard University, 2013
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