| 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data JK Nicholson, JC Lindon, E Holmes Xenobiotica 29 (11), 1181-1189, 1999 | 4533 | 1999 |
| Host-gut microbiota metabolic interactions JK Nicholson, E Holmes, J Kinross, R Burcelin, G Gibson, W Jia, ... Science 336 (6086), 1262-1267, 2012 | 3674 | 2012 |
| Metabonomics: a platform for studying drug toxicity and gene function JK Nicholson, J Connelly, JC Lindon, E Holmes Nature reviews Drug discovery 1 (2), 153-161, 2002 | 2432 | 2002 |
| Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts O Beckonert, HC Keun, TMD Ebbels, J Bundy, E Holmes, JC Lindon, ... Nature protocols 2 (11), 2692, 2007 | 1990 | 2007 |
| Metabonomics JK Nicholson, JC Lindon Nature 455 (7216), 1054-1056, 2008 | 1974 | 2008 |
| Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics JT Brindle, H Antti, E Holmes, G Tranter, JK Nicholson, HWL Bethell, ... Nature medicine 8 (12), 1439-1445, 2002 | 1341 | 2002 |
| Understanding'global'systems biology: metabonomics and the continuum of metabolism JK Nicholson, ID Wilson Nature Reviews Drug Discovery 2 (8), 668-676, 2003 | 1288 | 2003 |
| OPLS discriminant analysis: combining the strengths of PLS‐DA and SIMCA classification M Bylesjö, M Rantalainen, O Cloarec, JK Nicholson, E Holmes, J Trygg Journal of Chemometrics: A Journal of the Chemometrics Society 20 (8‐10 …, 2006 | 1270 | 2006 |
| Symbiotic gut microbes modulate human metabolic phenotypes M Li, B Wang, M Zhang, M Rantalainen, S Wang, H Zhou, Y Zhang, ... Proceedings of the National Academy of Sciences 105 (6), 2117-2122, 2008 | 1176 | 2008 |
| 750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma JK Nicholson, PJD Foxall, M Spraul, RD Farrant, JC Lindon Analytical chemistry 67 (5), 793-811, 1995 | 1140 | 1995 |
| Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice ME Dumas, RH Barton, A Toye, O Cloarec, C Blancher, A Rothwell, ... Proceedings of the national academy of sciences 103 (33), 12511-12516, 2006 | 1138 | 2006 |
| Human metabolic phenotype diversity and its association with diet and blood pressure E Holmes, RL Loo, J Stamler, M Bictash, IKS Yap, Q Chan, T Ebbels, ... Nature 453 (7193), 396-400, 2008 | 1102 | 2008 |
| Gut microorganisms, mammalian metabolism and personalized health care JK Nicholson, E Holmes, ID Wilson Nature Reviews Microbiology 3 (5), 431-438, 2005 | 1085 | 2005 |
| Gut microbiomes of Malawian twin pairs discordant for kwashiorkor MI Smith, T Yatsunenko, MJ Manary, I Trehan, R Mkakosya, J Cheng, ... Science 339 (6119), 548-554, 2013 | 1075 | 2013 |
| Impact of the gut microbiota on inflammation, obesity, and metabolic disease CL Boulangé, AL Neves, J Chilloux, JK Nicholson, ME Dumas Genome medicine 8 (1), 1-12, 2016 | 950 | 2016 |
| Pharmaco-metabonomic phenotyping and personalized drug treatment T Andrew Clayton, JC Lindon, O Cloarec, H Antti, C Charuel, G Hanton, ... Nature 440 (7087), 1073-1077, 2006 | 950 | 2006 |
| Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets O Cloarec, ME Dumas, A Craig, RH Barton, J Trygg, J Hudson, ... Analytical chemistry 77 (5), 1282-1289, 2005 | 921 | 2005 |
| Global metabolic profiling procedures for urine using UPLC–MS EJ Want, ID Wilson, H Gika, G Theodoridis, RS Plumb, J Shockcor, ... Nature protocols 5 (6), 1005-1018, 2010 | 829 | 2010 |
| Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism TA Clayton, D Baker, JC Lindon, JR Everett, JK Nicholson Proceedings of the National Academy of Sciences 106 (34), 14728-14733, 2009 | 777 | 2009 |
| Metabolic phenotyping in health and disease E Holmes, ID Wilson, JK Nicholson Cell 134 (5), 714-717, 2008 | 767 | 2008 |
Elaine HolmesMurdoch University & Imperial College LondonVerified email at imperial.ac.uk
