Shivakumar Vasanth
Shivakumar Vasanth
Study Director, Metabolism, Covance Laboratories
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Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease
SH Low, S Vasanth, CH Larson, S Mukherjee, N Sharma, MT Kinter, ...
Developmental cell 10 (1), 57-69, 2006
Polycystin-1 regulates STAT activity by a dual mechanism
JJ Talbot, JM Shillingford, S Vasanth, N Doerr, S Mukherjee, MT Kinter, ...
PNAS 108 (19), 7985, 2011
Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4
SA Riazuddin, S Vasanth, N Katsanis, JD Gottsch
The American Journal of Human Genetics 93 (4), 758-764, 2013
Metabolic regulation and energy homeostasis through the primary Cilium
EC Oh, S Vasanth, N Katsanis
Cell metabolism 21 (1), 21-31, 2015
Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease
HS Kang, G ZeRuth, K Lichti-Kaiser, S Vasanth, Z Yin, YS Kim, AM Jetten
Histology and histopathology 25 (11), 1481, 2010
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy
AS Benischke, S Vasanth, T Miyai, KR Katikireddy, T White, Y Chen, ...
Scientific reports 7 (1), 1-11, 2017
Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease
K Lichti-Kaiser, G ZeRuth, HS Kang, S Vasanth, AM Jetten
Vitamins & Hormones 88, 141-171, 2012
Expansion of CTG18. 1 trinucleotide repeat in TCF4 is a potent driver of Fuchs' corneal dystrophy
S Vasanth, AO Eghrari, BC Gapsis, J Wang, NF Haller, WJ Stark, ...
Investigative ophthalmology & visual science 56 (8), 4531-4536, 2015
Dosage changes of a segment at 17p13. 1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes
CMB Carvalho, S Vasanth, M Shinawi, C Russell, MB Ramocki, ...
The American Journal of Human Genetics 95 (5), 565-578, 2014
FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1
SY Khan, S Vasanth, F Kabir, JD Gottsch, AO Khan, R Chaerkady, ...
Nature communications 7 (1), 1-15, 2016
Identification of nuclear localization, DNA binding, and transactivating mechanisms of Krüppel-like zinc finger protein Gli-similar 2 (Glis2)
S Vasanth, G ZeRuth, HS Kang, AM Jetten
Journal of Biological Chemistry 286 (6), 4749-4759, 2011
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy
KR Katikireddy, TL White, T Miyajima, S Vasanth, D Raoof, Y Chen, ...
Free Radical Biology and Medicine 116, 19-30, 2018
Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected
C Liu, T Miyajima, G Melangath, T Miyai, S Vasanth, N Deshpande, ...
Proceedings of the National Academy of Sciences 117 (1), 573-583, 2020
CTG18. 1 expansion in TCF4 increases likelihood of transplantation in Fuchs corneal dystrophy
AO Eghrari, S Vasanth, J Wang, F Vahedi, SA Riazuddin, JD Gottsch
Cornea 36 (1), 40, 2017
Activation of PINK1-parkin–mediated mitophagy degrades mitochondrial quality control proteins in fuchs endothelial corneal dystrophy
T Miyai, S Vasanth, G Melangath, N Deshpande, V Kumar, AS Benischke, ...
The American journal of pathology 189 (10), 2061-2076, 2019
Generation and proteome profiling of PBMC-originated, iPSC-derived corneal endothelial cells
M Ali, SY Khan, S Vasanth, MR Ahmed, R Chen, CH Na, JJ Thomson, ...
Investigative ophthalmology & visual science 59 (6), 2437-2444, 2018
Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy
T Miyajima, G Melangath, S Zhu, N Deshpande, S Vasanth, B Mondal, ...
Free Radical Biology and Medicine 147, 69-79, 2020
N-Acetylcysteine alleviates progression of Fuchs endothelial corneal dystrophy in a UVA irradiation-induced mouse model
C Liu, T Miyajima, S Vasanth, T Miyai, B Farinelli, UV Jurkunas
Investigative Ophthalmology & Visual Science 59 (9), 1356-1356, 2018
NQO1 downregulation generates genotoxic DNA adducts in in vitro FECD model
T Miyajima, S Vasanth, G Melangath, N Deshpande, Y Chen, M Zahid, ...
Investigative Ophthalmology & Visual Science 60 (9), 2177-2177, 2019
Identification of a novel TCF4 isoform in human corneal endothelium
AO Eghrari, S Vasanth, BC Gapsis, H Bison, U Jurkunas, SA Riazuddin, ...
Cornea 37 (7), 899, 2018
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